The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Analysis of neighboring aromatic groups in four biphenyl peptides or peptide analogs and
34 proteins reveals a specific aromatic-aromatic interaction. Aromatic pairs (< 7 Å between …

Proteins are structurally dynamic macromolecules, and it is challenging to quantify the
conformational properties of their native state in solution. Nanopores can be efficient tools to …

Directed movement is a characteristic of many living organisms and occurs as a result of the
transformation of chemical energy into mechanical energy. Myosin is one of three families of …

DnaK and other members of the 70-kilodalton heat-shock protein (hsp70) family promote
protein folding, interaction, and translocation, both constitutively and in response to stress …

The 'EF-hand'Ca2+-binding motif plays an essential role in eukaryotic cellular signalling,
and the proteins containing this motif constitute a large and functionally diverse family. The …

The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the
coupling of excitation and contraction in cardiac muscle. Among various modulators …

The crystal structure of mammalian calmodulin has been refined at 2.2 Å (1 Å= 0.1 nm)
resolution using a restrained least-squares method. The final crystallographic R-factor …

Calmodulin (CaM) is a ubiquitous, highly conserved, eukaryotic protein that binds to and
regulates a number of diverse target proteins involved in different functions such as …

The three-dimensional solution structure of the complex between calcium-bound calmodulin
(Ca2+-CaM) and a 26-residue synthetic peptide comprising the CaM binding domain …