Macrophage polarization and osteoporosis: a review

J Muñoz, NS Akhavan, AP Mullins, BH Arjmandi - Nutrients, 2020 - mdpi.com
Over 200 million people suffer from osteoporosis worldwide. Individuals with osteoporosis
have increased rates of bone resorption while simultaneously having impaired …

The multifaceted roles of macrophages in bone regeneration: a story of polarization, activation and time

C Schlundt, H Fischer, CH Bucher, C Rendenbach… - Acta biomaterialia, 2021 - Elsevier
To present knowledge, macrophages are found in all tissues of the human body. They are a
cell population with high plasticity which come with a multitude of functions which appear to …

[HTML][HTML] Macrophages in osteoarthritis: pathophysiology and therapeutics

Y Chen, W Jiang, H Yong, M He, Y Yang… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is
characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain …

Communications between bone marrow macrophages and bone cells in bone remodeling

K Chen, Y Jiao, L Liu, M Huang, C He, W He… - Frontiers in Cell and …, 2020 - frontiersin.org
The mammalian skeleton is a metabolically active organ that continuously undergoes bone
remodeling, a process of tightly coupled bone resorption and formation throughout life …

Insights into the role of macrophage polarization in the pathogenesis of osteoporosis

W Wang, H Liu, T Liu, H Yang… - Oxidative medicine and …, 2022 - Wiley Online Library
Millions of people worldwide suffer from osteoporosis, which causes bone fragility and
increases the risk of fractures. Osteoporosis is closely related to the inhibition of …

Changes in interstitial fluid flow, mass transport and the bone cell response in microgravity and normogravity

F Wei, K Flowerdew, M Kinzel, LE Perotti, J Asiatico… - Bone Research, 2022 - nature.com
In recent years, our scientific interest in spaceflight has grown exponentially and resulted in
a thriving area of research, with hundreds of astronauts spending months of their time in …

METTL3 modulates osteoclast differentiation and function by controlling RNA stability and nuclear export

D Li, L Cai, R Meng, Z Feng, Q Xu - International Journal of Molecular …, 2020 - mdpi.com
Osteoclast differentiation and function are crucial for maintaining bone homeostasis and
preserving skeletal integrity. N6-methyladenosine (m6A) is an abundant mRNA modification …

Multi-functional cerium oxide nanoparticles regulate inflammation and enhance osteogenesis

F Wei, CJ Neal, TS Sakthivel, T Kean, S Seal… - Materials Science and …, 2021 - Elsevier
Oxidative stress increases bone loss and limits repair, in part, through immunoregulation
and the formation and maintenance of low-grade chronic inflammation. The aim of this study …

Dual-targeted nanodiscs revealing the cross-talk between osteogenic differentiation of mesenchymal stem cells and macrophages

L Chen, C Yu, W Xu, Y Xiong, P Cheng, Z Lin… - ACS …, 2023 - ACS Publications
Ongoing research has highlighted the significance of the cross-play of macrophages and
mesenchymal stem cells (MSCs). Lysine-specific demethylase 6B (KDM6B) has been …

Enhanced osteogenesis and angiogenesis of calcium phosphate cement incorporated with zinc silicate by synergy effect of zinc and silicon ions

T Lu, J Zhang, X Yuan, C Tang, X Wang… - Materials Science and …, 2021 - Elsevier
Calcium phosphate cement (CPC) with good injectability and osteoconductivity plays
important roles in bone grafting application. Much attention has been paid to achieve …