Nuclear factor erythroid 2-related factor 2 (Nrf2) is a vital transcription factor and its induction
is of significant importance for protecting against oxidative damage. Increased levels of …

Regulatory role of Sirtuin 1 (SIRT1), one of the most extensively studied members of its kind
in histone deacetylase family in governing multiple cellular fates, is predominantly linked to …

Malignant stem cells have long been considered a key therapeutic target in leukemia.
Therapeutic strategies designed to target the fundamental biology of leukemia stem cells …

Aging of organisms begins from a single cell at the molecular level. It includes changes
related to telomere shortening, cell senescence and epigenetic modifications. These …

Background Congenital malformations can be manifested as combinations of phenotypes
that co-occur more often than expected by chance. In many such cases, it has proved difficult …

Understanding how cell fate decisions are regulated is a fundamental goal of developmental
and stem cell biology. Most studies on the control of cell fate decisions address the …

Cisplatin‐(CDDP) induced acute kidney injury (AKI) limits the clinical use of cisplatin.
Several sirtuin (SIRT) family proteins are involved in AKI, while the roles of Sirt5 in cisplatin …

Osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) plays an
essential role in bone formation. Its imbalance can lead to osteoporosis. Estrogen and long …

Parkinson's disease (PD) is the second most common neurodegenerative disease and is
known to involve circadian dysfunction and oxidative stress. Although antioxidative defense …

Stimulation of the cytosolic NAD+ dependent deacetylase SIRT1 is cardioprotective against
ischemia-reperfusion (IR) injury. NAD+ precursors including nicotinamide mononucleotide …