Pulmonary surfactant is a lipid–protein complex that lines and stabilizes the respiratory
interface in the alveoli, allowing for gas exchange during the breathing cycle. At the same …

The acute inflammatory airway response is characterized by a time-dependent onset
followed by active resolution. Emerging evidence suggests that epithelial cells of the …

The human innate host defense molecules, SP-A1 and SP-A2 variants, differentially affect
survival after infection in mice and in lung transplant patients. SP-A interacts with the …

Pulmonary surfactant, a lipoprotein complex, maintains alveolar integrity and plays an
important role in lung host defense, and control of inflammation. Altered inflammatory …

Surfactant proteins (SP) are involved in surfactant function and innate immunity in the
human lung. Both lung function and innate immunity are altered in CF, and altered SP levels …

Surfactant protein A (SP-A) enhances phagocytosis of Pseudomonas aeruginosa. SP-A1
and SP-A2 encode human (h) SP-A; SP-A2 products enhance phagocytosis more than SP …

Ambient ozone is a criteria air pollutant that impacts both human morbidity and mortality. The
effect of ozone inhalation includes both toxicity to lung tissue and alteration of the host …

Innate immunity mechanisms play a critical role in the primary response to invading
pathogenic microorganisms and other insulting agents. The innate lung immune system …

Pulmonary surfactant is a lipoprotein complex that reduces surface tension to prevent
alveolar collapse and contributes to the protection of the respiratory surface from the entry of …

Pulmonary surfactant is a heterogeneous active surface complex made up of lipids and
proteins. The major glycoprotein in surfactant is surfactant protein A (SP-A), which is …