The effect of antifungal resistance development on the virulence of Candida species

F Bohner, C Papp, A Gácser - FEMS Yeast Research, 2022 - academic.oup.com
In recent years, the relevance of diseases associated with fungal pathogens increased
worldwide. Members of the Candida genus are responsible for the greatest number of fungal …

Host–pathogen interaction in Candida glabrata infection: current knowledge and implications for antifungal therapy

M Rasheed, A Battu, R Kaur - Expert Review of Anti-infective …, 2020 - Taylor & Francis
Introduction The opportunistic fungal pathogen Candida glabrata poses a clinical challenge
in the successful treatment of invasive Candida infections, owing to its low inherent …

[HTML][HTML] Phosphatidylinositol 3-phosphate regulates iron transport via PI3P-binding CgPil1 protein

F Askari, B Vasavi, R Kaur - Cell Reports, 2023 - cell.com
Iron homeostasis, which is pivotal to virulence, is regulated by the phosphatidylinositol 3-
kinase CgVps34 in the human fungal pathogen Candida glabrata. Here, we identify CgPil1 …

The SET-domain protein CgSet4 negatively regulates antifungal drug resistance via the ergosterol biosynthesis transcriptional regulator CgUpc2a

P Bhakt, M Raney, R Kaur - Journal of Biological Chemistry, 2022 - ASBMB
Invasive fungal infections, which pose a serious threat to human health, are increasingly
associated with a high mortality rate and elevated health care costs, owing to rising …

Two functionally redundant FK506-binding proteins regulate multidrug resistance gene expression and govern azole antifungal resistance

R Moirangthem, K Kumar, R Kaur - Antimicrobial Agents and …, 2021 - Am Soc Microbiol
Increasing resistance to antifungal therapy is an impediment to the effective treatment of
fungal infections. Candida glabrata is an opportunistic human fungal pathogen that is …

Impact of Fab1/Vac14 inhibition on β-1, 3-glucanase localization at the tip in Saccharomyces cerevisiae

S Takeshita, Y Iida - Biochemical and Biophysical Research …, 2024 - Elsevier
Deep mycosis is a severe fungal disease that could result in fatal outcomes. However, there
is still a demand for highly effective and safe antifungal drugs, given the side effects of the …

[HTML][HTML] An actin depolymerizing agent 19, 20-epoxycytochalasin Q of Xylaria sp. BCC 1067 enhanced antifungal action of azole drugs through ROS-mediated cell …

P Somboon, N Soontorngun - Microbiological Research, 2021 - Elsevier
Multidrug resistance is a highly conserved phenomenon among all living organisms and a
major veritable public health problem worldwide. Repetitive uses of antibiotics lead to …

Essential Role for the Phosphatidylinositol 3,5-Bisphosphate Synthesis Complex in Caspofungin Tolerance and Virulence in Candida glabrata

DK Choudhary, P Bhakt, R Kaur - Antimicrobial Agents and …, 2019 - Am Soc Microbiol
Increasing resistance of the human opportunistic fungal pathogen Candida glabrata toward
the echinocandin antifungals, which target the cell wall, is a matter of grave clinical concern …

Zap1 is required for Candida glabrata response to fluconazole

A Gaspar-Cordeiro, G Afonso, C Amaral… - FEMS Yeast …, 2022 - academic.oup.com
The increasing prevalence of fluconazole-resistant clinical isolates of Candida spp. strongly
hinders the widespread use of the drug. To tackle this problem, great efforts have been …

Drug repurposing: Fast-tracking Antifungal drug discovery for Cryptococcal Meningitis

M Truong - 2019 - opus.lib.uts.edu.au
Cryptococcal meningitis is the most common form of meningitis in HIV‐infected persons. It is
a life-threatening fungal infection of the brain that disproportionately affects the poorest and …