Highlights•Modulation of synaptic strength can occur through changes in short-term
plasticity.•Modulators can shape or induce long-term synaptic plasticity.•Modulators can …

The cardiac voltage-gated Na+ channel, Na V 1.5, is responsible for the upstroke of the
action potential in cardiomyocytes and for efficient propagation of the electrical impulse in …

Voltage-gated sodium channels carry the major inward current responsible for action
potential depolarization in excitable cells as well as providing additional inward current that …

Voltage-gated sodium channels (Navs) are critical determinants of cellular excitability.
These ion channels exist as large heteromultimeric structures and their activity is tightly …

The FGF14 protein controls biophysical properties and subcellular distribution of neuronal
voltage-gated Na+(Nav) channels through direct binding to the channel C terminus. To gain …

Glycogen synthase kinase 3β (GSK3) is a multifaceted serine/threonine (S/T) kinase
expressed in all eukaryotic cells. GSK3β is highly enriched in neurons in the central nervous …

Resilience and vulnerability to neuropsychiatric disorders are linked to molecular changes
underlying excitability that are still poorly understood. Here, we identify glycogen-synthase …

Voltage-gated sodium channels (Nav1. 1–Nav1. 9) are responsible for the initiation and
propagation of action potentials in neurons, controlling firing patterns, synaptic transmission …

Voltage-gated sodium (Nav) channels initiate action potentials in brain neurons and are
primary therapeutic targets for anti-epileptic drugs controlling neuronal hyperexcitability in …

Glycogen synthase kinase 3beta (GSK-3β) is an enzyme with a variety of cellular functions
in addition to the regulation of glycogen metabolism. In the central nervous system, different …