Liposomes and extracellular vesicles as drug delivery systems: A comparison of composition, pharmacokinetics, and functionalization

L van der Koog, TB Gandek… - Advanced healthcare …, 2022 - Wiley Online Library
Over the past decades, lipid‐based nanoparticle drug delivery systems (DDS) have caught
the attention of researchers worldwide, encouraging the field to rapidly develop improved …

The pros and cons of mesenchymal stem cell-based therapies

A Musiał-Wysocka, M Kot, M Majka - Cell transplantation, 2019 - journals.sagepub.com
The need to search for new, alternative treatments for various diseases has prompted
scientists and physicians to focus their attention on regenerative medicine and broadly …

Mesenchymal stem cell–derived exosomes: a promising biological tool in nanomedicine

W Wei, Q Ao, X Wang, Y Cao, Y Liu… - Frontiers in …, 2021 - frontiersin.org
As nano-scale biological vesicles, extracellular vesicles (EVs)/exosomes, in particular,
exosomes derived from mesenchymal stem cells (MSC-exosomes), have been studied in …

[HTML][HTML] Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities

S Varderidou-Minasian, MJ Lorenowicz - Theranostics, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem/stromal cells (MSCs) are important players in tissue homeostasis and
regeneration owing to their immunomodulatory potential and release of trophic factors that …

Extracellular vesicles for tissue repair and regeneration: Evidence, challenges and opportunities

A Nagelkerke, M Ojansivu, L van der Koog… - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are biological nanoparticles naturally secreted by cells, acting
as delivery vehicles for molecular messages. During the last decade, EVs have been …

Functional proteins of mesenchymal stem cell-derived extracellular vesicles

G Qiu, G Zheng, M Ge, J Wang, R Huang… - Stem cell research & …, 2019 - Springer
Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs,
and phospholipids, and are a novel mechanism of intercellular communication. It has been …

Mesenchymal stem cell-based cell-free strategies: safe and effective treatments for liver injury

C Hu, L Zhao, L Zhang, Q Bao, L Li - Stem Cell Research & Therapy, 2020 - Springer
Various hepatoxic factors, such as viruses, drugs, lipid deposition, and autoimmune
responses, induce acute or chronic liver injury, and 3.5% of all worldwide deaths result from …

Extracellular vesicles as an efficient and versatile system for drug delivery

XTT Dang, JM Kavishka, DX Zhang, M Pirisinu, MTN Le - Cells, 2020 - mdpi.com
Despite the recent advances in drug development, the majority of novel therapeutics have
not been successfully translated into clinical applications. One of the major factors hindering …

Heterogeneity of mesenchymal stem cell-derived extracellular vesicles is highly impacted by the tissue/cell source and culture conditions

C Almeria, S Kreß, V Weber, D Egger, C Kasper - Cell & Bioscience, 2022 - Springer
Extracellular vesicles (EVs) are cell-derived membrane structures exerting major effects in
physiological as well as pathological processes by functioning as vehicles for the delivery of …

Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells

Y Bi, X Qiao, Q Liu, S Song, K Zhu, X Qiu… - Stem Cell Research & …, 2022 - Springer
Background Increasing studies have reported the therapeutic effect of mesenchymal stem
cell (MSC)-derived exosomes by which protein and miRNA are clearly characterized …