During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the
cartilage, bone and connective tissue that make up the developing head. Although the initial …

The formation of the heart is a complex morphogenetic process that depends on the
spatiotemporally regulated contribution of cardiac progenitor cells. These mainly derive from …

Objective: To establish a classification of bicuspid aortic valve (BAV) that includes both
leaflet morphology and aortic shape. Setting: Two academic medical centres of the …

This review discusses the function of neural crest as they relate to cardiovascular defects.
The cardiac neural crest cells are a subpopulation of cranial neural crest discovered nearly …

Eye development has been a paradigm for the study of organogenesis, from the
demonstration of lens induction through epithelial tissue morphogenesis, to neuronal …

Bicuspid aortic valve (BAV) is the most common adult congenital heart defect and is found in
0.5% to 2.0% of the general population. The term “BAV” refers to a heterogeneous group of …

Blimp1, a zinc-finger containing DNA-binding transcriptional repressor, functions as a
master regulator of B cell terminal differentiation. Considerable evidence suggests that …

Insight into the mechanisms underlying congenital heart defects and the use of stem cells for
cardiac repair are major research goals in cardiovascular biology. In the early embryo …

To bypass the essential gastrulation function of Fgf8 and study its role in lineages of the
primitive streak, we have used a new mouse line, T-Cre, to generate mouse embryos with …

Neural crest cells are multipotential cells that delaminate from the dorsal neural tube and
migrate widely throughout the body. A subregion of the cranial neural crest originating …