Abstract Src homology 3 (SH3) domains are involved in the regulation of important cellular
pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of …

The adaptor proteins Crk (CT10 (chicken tumor virus number 10) regulator of kinase),
including CrkI, CrkII and Crk‐like, are important signal molecules that regulate a variety of …

CrkL is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. CrkL is
thought to adopt a structure that is similar to that of its CrkII homolog. The two proteins share …

The Crk family of adaptor proteins (CrkI, CrkII, and CrkL), originally discovered as the
oncogene fusion product, v-Crk, of the CT10 chicken retrovirus, lacks catalytic activity but …

Cyclophilin A (CypA) is overexpressed in a number of human cancer types, but the
mechanisms by which the protein promotes oncogenic properties of cells are not …

Although c-Abl and Arg non–receptor tyrosine kinases are well known for driving leukemia
development, their role in solid tumors has not been appreciated until recently …

Simple Summary Protein tyrosine kinases (PTKs) are classified into two groups: one group
includes tyrosine kinases, and the second group includes serine/threonine kinases. The …

The activity of Src family kinases (Src being the prototypical member) is tightly regulated by
differential phosphorylation on Tyr416 (positive) and Tyr527 (negative), a duet that …

Background SH3 domains are eukaryotic protein domains that participate in a plethora of
cellular processes including signal transduction, proliferation, and cellular movement …

The N-terminal Src homology 3 (nSH3) domain of a signaling adaptor protein, CT-10
regulator of kinase II (CrkII), recognizes proline-rich motifs (PRMs) of binding partners, such …