The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

The reproductive endocrine systems are vastly different between males and females. This
sexual dimorphism of the endocrine milieu originates from sex-specific differentiation of the …

Sex determination in mammals depends on the differentiation of the supporting lineage of
the gonads into Sertoli or pregranulosa cells that govern testis and ovary development …

Origin of the adrenogonadal primordium The adrenal glands develop from 2 separate
embryologic tissues: the medulla is derived from neural crest cells originating in proximity to …

Neuroblastoma is the most common extracranial solid tumor and accounts for∼ 10% of
pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is …

The adult human adrenal cortex produces steroid hormones that are crucial for life,
supporting immune response, glucose homeostasis, salt balance and sexual maturation. It …

The adrenal cortex undergoes remodeling during fetal and postnatal life. How zona
reticularis emerges in the postnatal gland to support adrenarche, a process whereby higher …

Adrenal glands are zonated endocrine organs that are essential in controlling body
homeostasis. How zonation is induced and maintained and how renewal of the adrenal …

Development of the adrenal cortex, a vital endocrine organ, originates in the adrenogonadal
primordium, a common progenitor for both the adrenocortical and gonadal lineages in …

The adrenal cortex undergoes multiple structural and functional rearrangements to satisfy
the systemic needs for steroids during fetal life, postnatal development, and adulthood. A …