Nucleic acids have been among the first targets for antitumor drugs and antibiotics. With the
unveiling of new biological roles in regulation of gene expression, specific DNA and RNA …

Enzyme-induced carbonate precipitation (EICP) is a relatively new bio-cementation
technique for ground improvement. In EICP, calcium carbonate (CaCO 3) precipitation …

Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still
needed, particularly for individuals in whom vaccines are less effective, such as the …

Covalent inhibition has become more accepted in the past two decades, as illustrated by the
clinical approval of several irreversible inhibitors designed to covalently modify their target …

Covalent inhibition is a reemerging paradigm in kinase drug design, but the roles of inhibitor
binding affinity and chemical reactivity in overall potency are not well-understood. To …

Telomerase reverse transcribes short guanine (G)-rich DNA repeat sequences from its
internal RNA template to maintain telomere length. G-rich telomere DNA repeats readily fold …

H-Ras, K-Ras, and N-Ras are small GTPases that are important in the control of cell
proliferation, differentiation, and survival, and their mutants occur frequently in human …

Although catalytic mechanisms in natural enzymes are well understood, achieving the
diverse palette of reaction chemistries in re-engineered native proteins has proved …

Ultrasmall Ni 2 P nanoparticles with dimensions around 3∼ 5 nm supported on SiO 2 (Ni-
P/SiO 2) and an Al 2 O 3-B 2 O 3 mixed oxide (Ni-P/AB) were prepared by a temperature …

Access to DNA packaged in nucleosomes is critical for gene regulation, DNA replication and
DNA repair. In humans, the UV-damaged DNA-binding protein (UV-DDB) complex detects …