Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that
regulates various biological processes, including proliferation, metastasis, angiogenesis …

As a transcription factor, STAT3 protein transduces extracellular signals to the nucleus and
then activates transcription of target genes. STAT3 has been well validated as an attractive …

Off-tissue effects are persistent issues of modern inhibition-based therapies. By merging the
strategies of photopharmacology and small-molecule degraders, we introduce a novel …

The lack of selectivity of anticancer drugs limits current chemotherapy. Light-activatable
drugs, whose activity can be precisely controlled with external light, could provide a more …

Signal transducer and activator of transcription (Stat) 3 is a valid anticancer therapeutic
target. We have discovered a highly potent chemotype that amplifies the Stat3-inhibitory …

We optimized our previously reported proline-based STAT3 inhibitors into an exciting new
series of (R)-azetidine-2-carboxamide analogues that have sub-micromolar potencies. 5a …

Cascade reactions are often 'employed'by nature to construct structurally diverse nitrogen-
containing heterocycles in a highly stereoselective fashion, ie, secondary metabolites …

SH2 domains have been recognized as promising targets for various human diseases.
However, targeting SH2 domains with phosphopeptides or small-molecule inhibitors derived …

The reactions of [RuCl (μ-Cl)(η 6-p-cymene)] 2 with sodium carboxylates, in methanol or
acetonitrile solution, afforded the complexes [RuCl (κ 2 O-RCO 2)(η 6-p-cymene)](RCO 2 …

STAT3 is a promising therapeutic target for the treatment of gastric cancer, which is one of
the most common solid tumors worldwide. In the previous works, we discovered a series of …