The tumor microenvironment comprises stromal and tumor cells which interact with each
other through complex cross-talks that are mediated by a variety of growth factors, cytokines …

The development of cancer is a multistep and complex process involving interactions
between tumor cells and the tumor microenvironment (TME). CXC chemokine ligand 13 …

Background We assessed the mechanism by which multiple myeloma (MM) shapes the
bone marrow (BM) microenvironment and affects MΦ polarization. Methods In vivo xenograft …

Abstract Approximately 15–40% of all cancers develop metastases in the central nervous
system (CNS), yet few therapeutic options exist to treat them. Cancer therapies based on …

Myeloid-derived suppressor cells (MDSC) represent a heterogeneous population of
immature myeloid cells. Under normal conditions, they differentiate into macrophages …

CXCL13, an inflammatory factor in the microenvironment, plays a vital role in the
progression of inflammatory diseases and tumors. CXCL13 and its receptor CXCR5 have …

Tumor microenvironment (eg, stromal cells) has been suggested to be implicated in
colorectal cancer (CRC) progression. Of which, cancer-associated fibroblasts (CAFs) are …

OBJECTIVE: CXCL13 plays a unique role in the trafficking and homing of B1 cells
associated with its cognate receptor, CXCR5. The CXCR5-CXCL13 axis has been …

Background: HIV infection is associated with a marked increase in risk for non-Hodgkin
lymphoma (AIDS-NHL). However, the mechanisms that promote the development of AIDS …

CXCR5 and/or CXCL13 expression is elevated in certain carcinomas and lymphomas. To
determine if these factors are involved in progression of non‑small cell lung cancer (LuCa) …