Diabetes mellitus predisposes affected individuals to a significant spectrum of
cardiovascular complications, one of the most debilitating in terms of prognosis is heart …

Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

The dramatic increase in the prevalence of obesity and its strong association with
cardiovascular disease have resulted in unprecedented interest in understanding the effects …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

Objectives: The purpose of this study was to compare myocardial triglyceride content and
function between patients with uncomplicated type 2 diabetes mellitus (T2DM) and healthy …

Summary High-fat-diet (HFD)-induced obesity is a major contributor to diabetes and
cardiovascular disease, but the underlying genetic mechanisms are poorly understood …

Metabolic disorders such as obesity, insulin resistance and type 2 diabetes mellitus are all
linked to cardiovascular diseases such as cardiac hypertrophy and heart failure. Diabetic …

The leading cause of death in diabetic patients is cardiovascular disease; diabetic
cardiomyopathy is typified by alterations in cardiac morphology and function, independent of …

Obesity and insulin resistance are associated with ectopic lipid deposition in multiple
tissues, including the heart. Excess lipid may be stored as triglycerides, but are also shunted …