[HTML][HTML] Macromolecular condensation buffers intracellular water potential

JL Watson, E Seinkmane, CT Styles, A Mihut… - Nature, 2023 - nature.com
Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

The physiological impact of the serum and glucocorticoid-inducible kinase SGK1

F Lang, F Artunc, V Vallon - Current opinion in nephrology and …, 2009 - journals.lww.com
The outlined recent findings advanced our understanding of the molecular regulation of
SGK1 as well as the role of the kinase in renal physiology and the pathophysiology of renal …

Significance of SGK1 in the regulation of neuronal function

F Lang, N Strutz‐Seebohm, G Seebohm… - The Journal of …, 2010 - Wiley Online Library
The present brief review highlights the putative role of the serum‐and glucocorticoid‐
inducible‐kinase‐1 (SGK1) in the regulation of neuronal function. SGK1 is genomically …

[HTML][HTML] Renal sodium gradient orchestrates a dynamic antibacterial defense zone

MR Berry, RJ Mathews, JR Ferdinand, C Jing… - Cell, 2017 - cell.com
Lower urinary tract infections are among the most common human bacterial infections, but
extension to the kidneys is rare. This has been attributed to mechanical forces, such as urine …

Osmolytes: Wonder molecules to combat protein misfolding against stress conditions

S Khan, S Siraj, M Shahid, MM Haque… - International Journal of …, 2023 - Elsevier
The proper functioning of any protein depends on its three dimensional conformation which
is achieved by the accurate folding mechanism. Keeping away from the exposed stress …

Neurotoxicity and gene‐expressed profile in brain‐injured mice caused by exposure to titanium dioxide nanoparticles

Y Ze, R Hu, X Wang, X Sang, X Ze, B Li… - … Research Part A: An …, 2014 - Wiley Online Library
Abstract Titanium dioxide nanoparticles (TiO2 NPs) are widely used in toothpastes,
sunscreens, and products for cosmetic purpose that the human use daily. Although the …

[HTML][HTML] Inositol transport proteins

S Schneider - FEBS letters, 2015 - Elsevier
The cyclic polyol myo-inositol is a key molecule in many different metabolic pathways
among all organisms; in addition, it is fundamental for osmotic balance in the mammalian …

Targeting SGK1 in diabetes

F Lang, A Görlach, V Vallon - Expert opinion on therapeutic targets, 2009 - Taylor & Francis
Compelling evidence is accumulating indicating a pathophysiological role of the serum-and-
glucocorticoid-inducible-kinase-1 (SGK1) in the development and complications of diabetes …

Myo‐inositol in health and disease: its impact on semen parameters and male fertility

MH Vazquez-Levin, GL Verón - Andrology, 2020 - Wiley Online Library
Abstract Background Myo‐inositol (cis‐1, 2, 3, 5‐trans‐4, 6‐cyclohexanehexol; MI) is the
most prominent of nine inositol stereoisomers. MI, its phosphate derivatives, and associated …

Comparative NMR metabolomics of the responses of A2780 human ovarian cancer cells to clinically established Pt-based drugs

V Ghini, F Magherini, L Massai, L Messori… - Dalton …, 2022 - pubs.rsc.org
Pt-Based drugs play a very important role in current cancer treatments; yet, their cellular and
mechanistic aspects are not fully understood. NMR metabolomics provides a powerful tool to …