The IQGAP scaffolds: Critical nodes bridging receptor activation to cellular signaling

L Thines, FJ Roushar, AC Hedman, DB Sacks - Journal of Cell Biology, 2023 - rupress.org
The scaffold protein IQGAP1 assembles multiprotein signaling complexes to influence
biological functions. Cell surface receptors, particularly receptor tyrosine kinases and G …

The antithetic roles of IQGAP2 and IQGAP3 in cancers

F Song, Q Dai, MO Grimm, D Steinbach - Cancers, 2023 - mdpi.com
Simple Summary The IQ motif-containing GTPase-activating protein family is comprised of
three signal scaffolding proteins that regulate a variety of biological functions by aiding …

EEF1A2 promotes HIF1A mediated breast cancer angiogenesis in normoxia and participates in a positive feedback loop with HIF1A in hypoxia

SA Patel, MK Hassan, M Naik, N Mohapatra… - British Journal of …, 2024 - nature.com
Background The eukaryotic elongation factor, EEF1A2, has been identified as an oncogene
in various solid tumors. Here, we have identified a novel function of EEF1A2 in …

N6-methyladenosine-modified ALDH9A1 modulates lipid accumulation and tumor progression in clear cell renal cell carcinoma through the NPM1/IQGAP2/AKT …

D Tan, D Miao, C Zhao, J Shi, Q Lv, F Lu, H Ruan… - Cell Death & …, 2024 - nature.com
Aldehyde dehydrogenases superfamily (ALDHs), which are ubiquitously present in various
organisms with diverse subcellular localizations, play a crucial role in regulating malignant …

Ras superfamily GTPase activating proteins in cancer: Potential therapeutic targets?

H Xiao, G Wang, M Zhao, W Shuai, L Ouyang… - European Journal of …, 2023 - Elsevier
To search more therapeutic strategies for Ras-mutant tumors, regulators of the Ras
superfamily involved in the GTP/GDP (guanosine triphosphate/guanosine diphosphate) …

Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle

KM Lin, LF Weng, SYJ Chen, SJ Lin, CH Tsai - Journal of Virology, 2023 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a human oncogenic γ-herpesvirus that establishes persistent
infection in more than 90% of the world's population. EBV has two life cycles, latency and …

Reduced IQGAP2 promotes bladder cancer through regulation of MAPK/ERK pathway and cytokines

F Song, R Kotolloshi, M Gajda, M Hölzer… - International journal of …, 2022 - mdpi.com
The progression of non-muscle-invasive bladder cancer (NMIBC) to muscle-invasive
bladder cancer (MIBC) is a major challenge in urologic oncology. However, understanding …

Role of IQ motif-containing GTPase-activating proteins in hepatocellular carcinoma

Q Dai, Q Ain, M Rooney, F Song, A Zipprich - Frontiers in Oncology, 2022 - frontiersin.org
IQ motif-containing GTPase-activating proteins (IQGAPs) are a class of scaffolding proteins,
including IQGAP1, IQGAP2, and IQGAP3, which govern multiple cellular activities by …

Reduced FRG1 expression promotes angiogenesis via activation of the FGF2‐mediated ERK/AKT pathway

B Mukherjee, P Brahma, T Mohapatra… - FEBS Open …, 2023 - Wiley Online Library
Identifying novel targets that control both tumorigenesis and angiogenesis can aid in
developing a more potent anti‐angiogenic therapeutic strategy. We previously reported that …

Sinensetin Inhibits Angiogenesis in Lung Adenocarcinoma via the miR-374c-5p/VEGF-A/VEGFR-2/AKT Axis

T Ji, L Ye, E Xi, Y Liu, X Wang, S Wang - Cell Biochemistry and Biophysics, 2024 - Springer
Sinensetin is a product isolated from Orthosiphon aristatus, and its antitumor activities have
been well established. This study focused on the role and mechanism of sinensetin in lung …