Sports drug testing using complementary matrices: advantages and limitations

M Thevis, H Geyer, L Tretzel, W Schänzer - Journal of pharmaceutical and …, 2016 - Elsevier
Today, routine doping controls largely rely on testing whole blood, serum, and urine
samples. These matrices allow comprehensively covering inorganic as well as low and high …

β‐Adrenergic modulation of skeletal muscle contraction: key role of excitation–contraction coupling

SP Cairns, F Borrani - The Journal of physiology, 2015 - Wiley Online Library
Our aim is to describe the acute effects of catecholamines/β‐adrenergic agonists on
contraction of non‐fatigued skeletal muscle in animals and humans, and explain the …

The impact of exercise-induced bronchoconstriction on athletic performance: a systematic review

OJ Price, JH Hull, V Backer, M Hostrup, L Ansley - Sports Medicine, 2014 - Springer
Background Exercise-induced bronchoconstriction (EIB) describes the phenomenon of
transient airway narrowing in association with physical activity. Although it may seem likely …

Anabolic and lipolytic actions of beta2‐agonists in humans and antidoping challenges

M Hostrup, GA Jacobson, S Jessen… - Drug Testing and …, 2020 - Wiley Online Library
Inhaled beta2‐adrenoceptor agonists (beta2‐agonists) are among the most used
substances in competitive sports. The 2020 Prohibited List issued by the World Anti‐Doping …

The potential role of oral fluid in antidoping testing

S Anizan, MA Huestis - Clinical chemistry, 2014 - academic.oup.com
BACKGROUND Currently, urine and blood are the only matrices authorized for antidoping
testing by the World Anti-Doping Agency (WADA). Although the usefulness of urine and …

Effects of acute and 2‐week administration of oral salbutamol on exercise performance and muscle strength in athletes

M Hostrup, A Kalsen, M Auchenberg… - … journal of medicine …, 2016 - Wiley Online Library
Our objective was to investigate effects of acute and 2‐week administration of oral
salbutamol on repeated sprint ability, exercise performance, and muscle strength in elite …

High-dose inhaled terbutaline increases muscle strength and enhances maximal sprint performance in trained men

M Hostrup, A Kalsen, J Bangsbo… - European journal of …, 2014 - Springer
Purpose The purpose of the present study was to investigate the effect of high-dose inhaled
terbutaline on muscle strength, maximal sprinting, and time-trial performance in trained men …

A physiologically based pharmacokinetic model of voriconazole in human CNS—Integrating time-dependent inhibition of CYP3A4, genetic polymorphisms of …

L Dong, X Zhuang, T Yang, K Yan, Y Cai - International Journal of …, 2024 - Elsevier
Objectives Voriconazole is a classical antifungal drug that is often used to treat CNS fungal
infections due to its permeability through the BBB. However, its clinical use remains …

Model‐based meta‐analysis of salbutamol pharmacokinetics and practical implications for doping control

P Courlet, T Buclin, J Biollaz, I Mazzoni… - CPT …, 2022 - Wiley Online Library
Salbutamol was included in the prohibited list of the World Anti‐Doping Agency (WADA) in
2004. Although systemic intake is banned, inhalation for asthma is permitted but with …

Quantitation of Formoterol, Salbutamol, and Salbutamol-4′-O-Sulfate in Human Urine and Serum via UHPLC-MS/MS

LC Harps, DA Bizjak, U Girreser, M Zügel… - Separations, 2023 - mdpi.com
The adrenergic beta-2 agonists formoterol and salbutamol are used for the treatment of
asthma and COPD but are also misused in sports competitions. Therefore, they are included …