Clinical development and potential of photothermal and photodynamic therapies for cancer

X Li, JF Lovell, J Yoon, X Chen - Nature reviews Clinical oncology, 2020 - nature.com
Light-activated, photosensitizer-based therapies have been established as safe modalities
of tumour ablation for numerous cancer indications. Two main approaches are available …

Block copolymer micelles in nanomedicine applications

H Cabral, K Miyata, K Osada, K Kataoka - Chemical reviews, 2018 - ACS Publications
Polymeric micelles are demonstrating high potential as nanomedicines capable of
controlling the distribution and function of loaded bioactive agents in the body, effectively …

Chemo-physical Strategies to Advance the in Vivo Functionality of Targeted Nanomedicine: The Next Generation

J Li, K Kataoka - Journal of the American Chemical Society, 2020 - ACS Publications
The past few decades have witnessed an evolution of nanomedicine from biologically inert
entities to more smart systems, aimed at advancing in vivo functionality. However, we should …

[HTML][HTML] Light-activated hypoxia-responsive nanocarriers for enhanced anticancer therapy

C Qian, J Yu, Y Chen, Q Hu, X Xiao, W Sun… - … (Deerfield Beach, Fla …, 2016 - ncbi.nlm.nih.gov
A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed
for efficiently producing singlet oxygen (1O2) and inducing hypoxia to promote release of its …

[HTML][HTML] Indocyanine green-incorporating nanoparticles for cancer theranostics

H Wang, X Li, BWC Tse, H Yang, CA Thorling, Y Liu… - Theranostics, 2018 - ncbi.nlm.nih.gov
Indocyanine green (ICG) is a near-infrared dye that has been used in the clinic for retinal
angiography, and defining cardiovascular and liver function for over 50 years. Recently …

Hypoxia-responsive nanoparticle based drug delivery systems in cancer therapy: an up-to-date review

R Kumari, D Sunil, RS Ningthoujam - Journal of Controlled Release, 2020 - Elsevier
Hypoxia is a salient feature observed in most solid malignancies that holds a pivotal role in
angiogenesis, metastasis and resistance to conventional cancer therapeutic approaches …

Photodynamic efficiency: from molecular photochemistry to cell death

IOL Bacellar, TM Tsubone, C Pavani… - International journal of …, 2015 - mdpi.com
Photodynamic therapy (PDT) is a clinical modality used to treat cancer and infectious
diseases. The main agent is the photosensitizer (PS), which is excited by light and converted …

Photoresponsive nanoparticles for drug delivery

AY Rwei, W Wang, DS Kohane - Nano today, 2015 - Elsevier
Externally triggerable drug delivery systems provide a strategy for the delivery of therapeutic
agents preferentially to a target site, presenting the ability to enhance therapeutic efficacy …

Photochemical mechanisms of light-triggered release from nanocarriers

N Fomina, J Sankaranarayanan, A Almutairi - Advanced drug delivery …, 2012 - Elsevier
Over the last three decades, a handful of photochemical mechanisms have been applied to
a large number of nanoscale assemblies that encapsulate a payload to afford spatio …

Biologically active molecules with a “light switch”

G Mayer, A Heckel - Angewandte Chemie International Edition, 2006 - Wiley Online Library
Biologically active compounds which are light‐responsive offer experimental possibilities
which are otherwise very difficult to achieve. Since light can be manipulated very precisely …