Abstract Cannon, Barbara, and Jan Nedergaard. Brown Adipose Tissue: Function and
Physiological Significance. Physiol Rev 84: 277–359, 2004; 10.1152/physrev. 00015.2003 …

The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …

Potassium channels are tetrameric membrane proteins that selectively conduct K+ across
cellular membranes. With 78 family members, K+ channels make up about half of the …

1. Ion channels and their possible relation to cell proliferation have been studied in a human
melanoma cell line (IGR 1). Membrane currents were recorded by the patch‐clamp …

Introduction: The voltage-dependent potassium channel Kv1. 3 is mainly present in the
nervous and immune systems. In leukocytes, Kv1. 3 fine-tunes the activation and …

Shear stress–induced activation of endothelial ion channels, one of the earliest responses to
flow, is implicated in mechano–signal transduction that results in the regulation of vascular …

Obesity is an epidemic, calling for innovative and reliable pharmacological strategies. Here,
we show that ShK-186, a selective and potent blocker of the voltage-gated Kv1. 3 channel …

Current strategies for cell-based screening generally focus on the development of highly
specific assays, which require an understanding of the nature of the signaling molecules …

Ion channels are transmembrane proteins that form aqueous pores driving ions through the
plasma membrane in favor of an electrochemical gradient. Thus, voltage-dependent …

The incidence of metabolic diseases—hypertension, diabetes, obesity, metabolic
dysfunction-associated steatotic liver disease (MASLD), and atherosclerosis—is increasing …