Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development

A Lismer, S Kimmins - Nature communications, 2023 - nature.com
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Sex differences in the intergenerational inheritance of metabolic traits

I Sandovici, DS Fernandez-Twinn, A Hufnagel… - Nature …, 2022 - nature.com
Strong evidence suggests that early-life exposures to suboptimal environmental factors,
including those in utero, influence our long-term metabolic health. This has been termed …

Paternal epigenetic influences on placental health and their impacts on offspring development and disease

SS Bhadsavle, MC Golding - Frontiers in Genetics, 2022 - frontiersin.org
Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

Frequency, morbidity and equity—the case for increased research on male fertility

S Kimmins, RA Anderson, CLR Barratt… - Nature Reviews …, 2024 - nature.com
Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

Reproductive and Metabolic Health Following Exposure to Environmental Chemicals: Mechanistic Insights from Mammalian Models

M Bellingham, NP Evans, RG Lea… - Annual Review of …, 2024 - annualreviews.org
The decline in human reproductive and metabolic health over the past 50 years is
associated with exposure to complex mixtures of anthropogenic environmental chemicals …

Mechanisms of transgenerational epigenetic inheritance: lessons from animal model organisms

F Santilli, A Boskovic - Current Opinion in Genetics & Development, 2023 - Elsevier
Epigenetic inheritance is a phenomenon whereby stochastic or signal-induced changes to
parental germline epigenome modulate phenotypic output in one or more subsequent …

Preconception origins of asthma, allergies and lung function: the influence of previous generations on the respiratory health of our children

C Svanes, JW Holloway… - Journal of Internal …, 2023 - Wiley Online Library
Emerging research suggests that exposures occurring years before conception are
important determinants of the health of future offspring and subsequent generations …

Inheritance of paternal lifestyles and exposures through sperm DNA methylation

KW Greeson, KMS Crow, RC Edenfield… - Nature Reviews …, 2023 - nature.com
Many different lifestyle factors and chemicals present in the environment are a threat to the
reproductive tracts of humans. The potential for parental preconception exposure to alter …

Higher incidence of embryonic defects in mouse offspring conceived with assisted reproduction from fathers with sperm epimutations

G Karahan, J Martel, S Rahimi, M Farag… - Human Molecular …, 2024 - academic.oup.com
Assisted reproductive technologies (ART) account for 1–6% of births in developed countries.
While most children conceived are healthy, increases in birth and genomic imprinting …

The association between long-term DDT or DDE exposures and an altered sperm epigenome—a cross-sectional study of Greenlandic Inuit and South African …

A Lismer, X Shao, MC Dumargne… - Environmental …, 2024 - ehp.niehs.nih.gov
Background: The organochlorine dichlorodiphenyltrichloroethane (DDT) is banned
worldwide owing to its negative health effects. It is exceptionally used as an insecticide for …