Key events ranging from cell polarity to proliferation regulation to neuronal signaling rely on
the assembly of multiprotein adhesion or signaling complexes at particular subcellular sites …

It is estimated that only 0.02% of disseminated tumour cells are able to seed overt
metastases. While this suggests the presence of environmental constraints to metastatic …

Semaphorins are a large family of developmental regulatory signals, characterized by
aberrant expression in human cancers. These molecules crucially control cell-cell …

Genome-wide association studies (GWAS) have identified more than 170 breast cancer
susceptibility loci. Here we hypothesize that some risk-associated variants might act in non …

Immune checkpoint inhibitors (ICIs) have caused revolutionary changes in cancer treatment,
but low response rates remain a challenge. Semaphorin 4A (Sema4A) modulates the …

Disruption of neocortical circuitry and architecture in humans causes numerous
neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by various …

Regulatory T (Treg) cells play a critical regulatory role in the immune system by suppressing
excessive immune responses and maintaining immune balance. The effective migration of …

The accessibility of cell surface proteins makes them tractable for targeting by cancer
immunotherapy, but identifying suitable targets remains challenging. Here we describe …

Semaphorins are a group of proteins that have been studied extensively for their critical
function in neuronal development. They have been shown to regulate airway development …

To understand how proper circuit formation and function is established in the mammalian
brain, it is necessary to define the genes and signaling pathways that instruct excitatory and …