The propagation of all organisms depends on the accurate and orderly segregation of
chromosomes in mitosis and meiosis. Budding yeast has long served as an outstanding …

Eukaryotic cells segregate their chromosomes accurately to opposite poles during mitosis,
which is necessary for maintenance of their genetic integrity. This process mainly relies on …

During eukaryotic cell division, the sister chromatids of duplicated chromosomes are pulled
apart by microtubules, which connect via kinetochores. The kinetochore is a multiprotein …

Regulation of macromolecular interactions by phosphorylation is crucial in signaling
networks. In the spindle assembly checkpoint (SAC), which enables errorless chromosome …

The spindle checkpoint is a conserved signaling pathway that ensures genomic integrity by
preventing cell division when chromosomes are not correctly attached to the spindle …

Kinetochores are nucleoprotein assemblies responsible for the attachment of chromosomes
to spindle microtubules during mitosis. The KMN network, a crucial constituent of the outer …

Kinetochores connect centromeric nucleosomes with mitotic-spindle microtubules through
conserved, cross-interacting protein subassemblies. In budding yeast, the heterotetrameric …

Chromosome biorientation on the mitotic spindle is prerequisite to errorless genome
inheritance. CENP‐E (kinesin‐7) and dynein–dynactin (DD), microtubule motors with …

The spindle assembly checkpoint (SAC) is a unique signalling mechanism that responds to
the state of attachment of the kinetochore to spindle microtubules. SAC signalling is …

Faithful chromosome segregation is mandatory for cell and organismal viability.
Kinetochores, large protein assemblies embedded in centromeric chromatin, establish a …