Cultivation of both human and non-human species of Plasmodium spp., the causal agent of
malaria, has been a major research success, leading to a greater understanding of the …

Publisher Summary This chapter discusses the complex factors regulating the infectivity of
the gametocyte to the mosquito vector and describes the patterns of parasite biology that …

Background Rodent malaria parasites (RMP) are used extensively as models of human
malaria. Draft RMP genomes have been published for Plasmodium yoelii, P. berghei ANKA …

Fertilization and zygote development are obligate features of the malaria parasite life cycle
and occur during parasite transmission to mosquitoes. The surface protein PFS48/45 is …

Gametocytes, the precursor cells of malaria-parasite gametes, circulate in the blood and are
responsible for transmission from host to mosquito vector. The individual proteomes of male …

A universal feature of metazoan sexual development is the generation of oocyte P granules
that withhold certain mRNA species from translation to provide coding potential for proteins …

The process of fertilization is critically dependent on the mutual recognition of gametes and
in Plasmodium, the male gamete surface protein P48/45 is vital to this process. This protein …

Malaria parasites and related Apicomplexans are the causative agents of the some of the
most serious infectious diseases of humans, companion animals, livestock and wildlife …

Plasmodium gene functions in mosquito and liver stages remain poorly characterized due to
limitations in the throughput of phenotyping at these stages. To fill this gap, we followed …

The ookinete is a motile stage in the malaria life cycle which forms in the mosquito blood
meal from the zygote. Ookinetes use an acto-myosin motor to glide towards and penetrate …