Molecular hybridization, synthesis, in vitro α-glucosidase inhibition, in vivo antidiabetic activity and computational studies of isatin based compounds
S Patil, SG Alegaon, S Gharge, SD Ranade… - Bioorganic …, 2024 - Elsevier
In the pursuit of novel antidiabetic agents, a series of isatin-thiazole derivatives (7a-7j) were
synthesized and characterized using a range of spectroscopic techniques. The enzyme …
synthesized and characterized using a range of spectroscopic techniques. The enzyme …
Key molecular scaffolds in the development of clinically viable α-amylase inhibitors
R Singh, J Sindhu, D Singh, P Kumar - Future Medicinal Chemistry, 2025 - Taylor & Francis
The escalating cases of type II diabetes combined with adverse side effects of current
antidiabetic drugs spurred the advancement of innovative approaches for the management …
antidiabetic drugs spurred the advancement of innovative approaches for the management …
Thiazolidine-2, 4-dione hybrids as dual alpha-amylase and alpha-glucosidase inhibitors: design, synthesis, in vitro and in vivo anti-diabetic evaluation
Twelve 3, 5-disubstituted-thiazolidine-2, 4-dione (TZD) hybrids were synthesized using
solution phase chemistry. Continuing our previous work, nine O-modified ethyl vanillin (8a–i) …
solution phase chemistry. Continuing our previous work, nine O-modified ethyl vanillin (8a–i) …
Novel sulfonyl hydrazide based β-carboline derivatives as potential α-glucosidase inhibitors: design, synthesis, and biological evaluation
J Sun, D Xiao, M Lang, X Xu - Molecular Diversity, 2024 - Springer
A series of novel sulfonyl hydrazide based β-carboline derivatives (SX1–SX32) were
designed and synthesized, and their structures were characterized on NMR and HRMS …
designed and synthesized, and their structures were characterized on NMR and HRMS …
Novel coumarin-thiazolidine-2, 4‑dione hybrids as potential α-glucosidase inhibitors: Synthesis and bioactivity evaluation
B Liang, J Li, S Wu, X Kou, T Liu, X Xu - Journal of Molecular Structure, 2025 - Elsevier
To discover novel α-glucosidase inhibitors, a series of coumarin-thiazolidine-2, 4‑dione
hybrids (BJX1∼ 20) were synthesized and assessed their inhibitory activities against α …
hybrids (BJX1∼ 20) were synthesized and assessed their inhibitory activities against α …
Synthesis, single crystal XRD, in vitro evaluation, molecular docking and ADMET studies of cuminaldehyde-thiazolidine-2, 4-dione hybrids as potential α-glucosidase …
A Paul, SS Mishra, A Sarkar, R Bhowmik, A De… - Journal of Molecular …, 2025 - Elsevier
In order to find effective α-glucosidase inhibitors, a series of cuminaldehyde-TZD hybrids
were designed, synthesized and evaluated for their α-glucosidase inhibitory activity by using …
were designed, synthesized and evaluated for their α-glucosidase inhibitory activity by using …
Novel α‐glucosidase Inhibitors Designed as Type 2 Diabetes Drugs by QSAR, Molecular Docking and Molecular Dynamics Simulation Methods
J Tong, J Yan, Y Zhang, X Xing - Chemistry & Biodiversity, 2025 - Wiley Online Library
Diabetes mellitus is a globally prevalent disease of significant concern. Alpha‐glucosidase
has emerged as a prominent target for the treatment of type 2 diabetes. In this study, 39 α …
has emerged as a prominent target for the treatment of type 2 diabetes. In this study, 39 α …