Cardiovascular diseases are the leading cause of death around the world. Despite the
larger number of genes and loci identified, the precise mechanisms by which these genes …

Cardiometabolic diseases encompass a range of interrelated conditions that arise from
underlying metabolic perturbations precipitated by genetic, environmental, and lifestyle …

Immune checkpoint inhibitors are widely used anticancer therapies that can cause morbid
and potentially fatal immune-related adverse events such as immune-related myocarditis …

Parkinson's disease (PD) is a progressive neurodegenerative disease highlighted by a
marked loss of dopaminergic cell loss and motor disturbances. Currently, there are no drugs …

The common forms of metabolic diseases are highly complex, involving hundreds of genes,
environmental and lifestyle factors, age-related changes, sex differences and gut …

Aims Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular
events and exhibit myocardial changes including left ventricular (LV) hypertrophy and …

Glycoprotein nonmetastatic melanoma protein B (GPNMB) is a type I transmembrane protein
initially identified in nonmetastatic melanomas and has been associated with human heart …

We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with
decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective …

In the event of a major accidental or intentional radiation exposure incident, the affected
population could suffer from total-or partial-body exposures to ionizing radiation with acute …

Multiple sclerosis (MS) is the main reason for disability caused by autoimmunity. However,
effective biomarkers for MS have not been identified. This study explored the molecular …