Two-metal-ion catalysis: Inhibition of DNA polymerase activity by a third divalent metal ion
J Wang, WH Konigsberg - Frontiers in Molecular Biosciences, 2022 - frontiersin.org
Almost all DNA polymerases (pols) exhibit bell-shaped activity curves as a function of both
pH and Mg2+ concentration. The pol activity is reduced when the pH deviates from the …
pH and Mg2+ concentration. The pol activity is reduced when the pH deviates from the …
Kinetic mechanism of DNA polymerases: contributions of conformational dynamics and a third divalent metal ion
Faithful transmission and maintenance of genetic material is primarily fulfilled by DNA
polymerases. During DNA replication, these enzymes catalyze incorporation of …
polymerases. During DNA replication, these enzymes catalyze incorporation of …
How DNA polymerases catalyse replication and repair with contrasting fidelity
DNA polymerases were named for their function of catalysing DNA replication, a process
that is necessary for growth and propagation of life. DNA involving Watson–Crick base …
that is necessary for growth and propagation of life. DNA involving Watson–Crick base …
Exploring the role of the third active site metal ion in DNA polymerase η with QM/MM free energy simulations
DR Stevens, S Hammes-Schiffer - Journal of the American …, 2018 - ACS Publications
The enzyme human DNA polymerase η (Pol η) is critical for bypassing lesions during DNA
replication. In addition to the two Mg2+ ions aligning the active site, experiments suggest …
replication. In addition to the two Mg2+ ions aligning the active site, experiments suggest …
Structure and function relationships in mammalian DNA polymerases
NM Hoitsma, AM Whitaker, MA Schaich… - Cellular and Molecular …, 2020 - Springer
DNA polymerases are vital for the synthesis of new DNA strands. Since the discovery of
DNA polymerase I in Escherichia coli, a diverse library of mammalian DNA polymerases …
DNA polymerase I in Escherichia coli, a diverse library of mammalian DNA polymerases …
Computational investigations of polymerase enzymes: Structure, function, inhibition, and biotechnology
I Geronimo, P Vidossich, E Donati… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
DNA and RNA polymerases (Pols) are central to life, health, and biotechnology because
they allow the flow of genetic information in biological systems. Importantly, Pol function and …
they allow the flow of genetic information in biological systems. Importantly, Pol function and …
Pyrophosphate release acts as a kinetic checkpoint during high-fidelity DNA replication by the Staphylococcus aureus replicative polymerase PolC
SP Fagan, P Mukherjee, WJ Jaremko… - Nucleic Acids …, 2021 - academic.oup.com
Bacterial replication is a fast and accurate process, with the bulk of genome duplication
being catalyzed by the α subunit of DNA polymerase III within the bacterial replisome …
being catalyzed by the α subunit of DNA polymerase III within the bacterial replisome …
Simulating the fidelity and the three Mg mechanism of pol η and clarifying the validity of transition state theory in enzyme catalysis
H Yoon, A Warshel - Proteins: Structure, Function, and …, 2017 - Wiley Online Library
Pol η belongs to the important Y family of DNA polymerases that can catalyze translesion
synthesis across sites of damaged DNA. This activity involves the reduced fidelity of Pol η for …
synthesis across sites of damaged DNA. This activity involves the reduced fidelity of Pol η for …
Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV‐1 reverse transcriptase: First crystal structures with reverse transcriptase …
N Bertoletti, AH Chan, RF Schinazi, YW Yin… - Protein …, 2019 - Wiley Online Library
The retrovirus HIV‐1 has been a major health issue since its discovery in the early 80s. In
2017, over 37 million people were infected with HIV‐1, of which 1.8 million were new …
2017, over 37 million people were infected with HIV‐1, of which 1.8 million were new …
Genes and cancer under magnetic control
AL Buchachenko, DA Kuznetsov - Russian Journal of Physical Chemistry B, 2021 - Springer
Many experimental observations convincingly demonstrate that the genes and genome as a
whole are sensitive to the magnetic fields, permanent and oscillating. The invasion of …
whole are sensitive to the magnetic fields, permanent and oscillating. The invasion of …