New horizons in the treatment of osteosarcoma

PS Meltzer, LJ Helman - New England Journal of Medicine, 2021 - Mass Medical Soc
Osteosarcoma Osteosarcoma, which is most common in people 10 to 30 years of age, is
generally treated with resection and adjuvant chemotherapy. Detection of gene …

Fibroblasts as turned agents in cancer progression

R Wieder - Cancers, 2023 - mdpi.com
Simple Summary Normal epithelial cells in our organs are surrounded by stroma, which is
an ecosystem made up of a variety of cells and proteins that support their intended functions …

Targeting LRRC15 inhibits metastatic dissemination of ovarian cancer

U Ray, DB Jung, L Jin, Y Xiao, S Dasari… - Cancer research, 2022 - AACR
Dissemination of ovarian cancer cells can lead to inoperable metastatic lesions in the bowel
and omentum that cause patient death. Here we show that LRRC15, a type-I 15-leucine–rich …

Receptors and cofactors that contribute to SARS-CoV-2 entry: can skin be an alternative route of entry?

M Barthe, L Hertereau, N Lamghari… - International Journal of …, 2023 - mdpi.com
To prevent the spread of SARS-CoV-2, all routes of entry of the virus into the host must be
mapped. The skin is in contact with the external environment and thus may be an alternative …

Exploiting LRRC15 as a novel therapeutic target in cancer

U Ray, CL Pathoulas, P Thirusangu, JW Purcell… - Cancer research, 2022 - AACR
Abundant fibrotic stroma is a typical feature of most solid tumors, and stromal activation
promotes oncogenesis, therapy resistance, and metastatic dissemination of cancer cells …

LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein

J Shilts, TWM Crozier, A Teixeira-Silva, I Gabaev… - PLoS …, 2023 - journals.plos.org
The interactions between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-
2) and human host factors enable the virus to propagate infections that lead to Coronavirus …

Antibody-drug conjugate targets, drugs, and linkers

BA Teicher, J Morris - Current Cancer Drug Targets, 2022 - ingentaconnect.com
Antibody-drug conjugates offer the possibility of directing powerful cytotoxic agents to a
malignant tumor while sparing normal tissue. The challenge is to select an antibody target …

Antibody conjugates for sarcoma therapy: how far along are we?

L Polito, G Calafato, M Bortolotti, C Chiarelli Olivari… - Biomedicines, 2021 - mdpi.com
Sarcomas are one of the most difficult type of cancer to manage and treat because of their
extremely heterogeneous molecular and morphological features. Despite the progress …

Dissecting the Molecular Basis of Host Leucine-Rich Repeat Containing 15 Mediated Interaction with Receptor Binding Domain of SARS-CoV-2 Spike Protein: A …

S Mishra, M Sharma, MK Singh, S Pati… - The Journal of Physical …, 2023 - ACS Publications
The detection of leucine-rich repeat containing 15 (LRRC15) as a connecting link with
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the possibility …

The origins, roles and therapies of cancer associated fibroblast in liver cancer

N Zulaziz, SJ Chai, KP Lim - Frontiers in Oncology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is the most common form of liver cancer. It is often
preceded by chronic inflammation such as liver fibrosis and cirrhosis. Different cell types are …