RNA-binding proteins in cancer: old players and new actors

B Pereira, M Billaud, R Almeida - Trends in cancer, 2017 - cell.com
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The
combination of versatility of their RNA-binding domains with structural flexibility enables …

RNA-binding proteins in cancer: functional and therapeutic perspectives

D Kang, Y Lee, JS Lee - Cancers, 2020 - mdpi.com
Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …

Cancer the 'RBP'eutics–RNA-binding proteins as therapeutic targets for cancer

S Mohibi, X Chen, J Zhang - Pharmacology & therapeutics, 2019 - Elsevier
RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

RNA-binding proteins in human genetic disease

KE Lukong, K Chang, EW Khandjian, S Richard - Trends in Genetics, 2008 - cell.com
RNA-binding proteins (RBPs) are key components in RNA metabolism, regulating the
temporal, spatial and functional dynamics of RNAs. Altering the expression of RBPs has …

SRC kinase-mediated signaling pathways and targeted therapies in breast cancer

J Luo, H Zou, Y Guo, T Tong, L Ye, C Zhu, L Deng… - Breast Cancer …, 2022 - Springer
Breast cancer (BC) has been ranked the most common malignant tumor throughout the
world and is also a leading cause of cancer-related deaths among women. SRC family …

Lessons in signaling and tumorigenesis from polyomavirus middle T antigen

MM Fluck, BS Schaffhausen - Microbiology and Molecular Biology …, 2009 - Am Soc Microbiol
The small DNA tumor viruses have provided a very long-lived source of insights into many
aspects of the life cycle of eukaryotic cells. In recent years, the emphasis has been on …

[HTML][HTML] RNA binding protein as an emerging therapeutic target for cancer prevention and treatment

S Hong - Journal of cancer prevention, 2017 - ncbi.nlm.nih.gov
After transcription, RNAs are always associated with RNA binding proteins (RBPs) to
perform biological activities. RBPs can interact with target RNAs in sequence-and structure …

Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

S Vanharanta, CB Marney, W Shu, M Valiente, Y Zou… - elife, 2014 - elifesciences.org
The mechanisms through which cancer cells lock in altered transcriptional programs in
support of metastasis remain largely unknown. Through integrative analysis of clinical breast …

The RNA-binding protein Sam68 is a multifunctional player in human cancer

P Bielli, R Busà, MP Paronetto… - Endocrine-related …, 2011 - erc.bioscientifica.com
Resistance to chemotherapy is a major complication in the treatment of advanced breast
cancer. Estrogens and prolactin (PRL) are implicated in the pathogenesis of breast cancer …

Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene

C Valacca, S Bonomi, E Buratti, S Pedrotti… - Journal of Cell …, 2010 - rupress.org
Epithelial-to-mesenchymal transition (EMT) and its reversal (MET) are crucial cell plasticity
programs that act during development and tumor metastasis. We have previously shown that …