The epithelial–mesenchymal plasticity landscape: principles of design and mechanisms of regulation

J Haerinck, S Goossens, G Berx - Nature Reviews Genetics, 2023 - nature.com
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …

Spontaneous deracemizations

T Buhse, JM Cruz, ME Noble-Teran… - Chemical …, 2021 - ACS Publications
Spontaneous deracemizations is a challenging, multidisciplinary subject in current chirality
research. In the absence of any chiral inductors, an achiral substance or a racemic …

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

OA Andreassen, GFL Hindley, O Frei… - World …, 2023 - Wiley Online Library
Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

A functional perspective on phenotypic heterogeneity in microorganisms

M Ackermann - Nature Reviews Microbiology, 2015 - nature.com
Most microbial communities consist of a genetically diverse assembly of different organisms,
and the level of genetic diversity plays an important part in community properties and …

Biological autonomy

A Moreno, M Mossio - A philo, 2015 - Springer
If we were to point out in a few words what characterises the phenomenon of life, we would
probably mention the amazing plasticity and robustness of living systems, the innumerable …

Functional roles for noise in genetic circuits

A Eldar, MB Elowitz - Nature, 2010 - nature.com
The genetic circuits that regulate cellular functions are subject to stochastic fluctuations, or
'noise', in the levels of their components. Noise, far from just a nuisance, has begun to be …

Phase separation provides a mechanism to reduce noise in cells

A Klosin, F Oltsch, T Harmon, A Honigmann, F Jülicher… - Science, 2020 - science.org
Expression of proteins inside cells is noisy, causing variability in protein concentration
among identical cells. A central problem in cellular control is how cells cope with this …

Stochastic gene expression in a single cell

MB Elowitz, AJ Levine, ED Siggia, PS Swain - Science, 2002 - science.org
Clonal populations of cells exhibit substantial phenotypic variation. Such heterogeneity can
be essential for many biological processes and is conjectured to arise from stochasticity, or …

Nature, nurture, or chance: stochastic gene expression and its consequences

A Raj, A Van Oudenaarden - Cell, 2008 - cell.com
Gene expression is a fundamentally stochastic process, with randomness in transcription
and translation leading to cell-to-cell variations in mRNA and protein levels. This variation …

Construction of a genetic toggle switch in Escherichia coli

TS Gardner, CR Cantor, JJ Collins - Nature, 2000 - nature.com
It has been proposed that gene-regulatory circuits with virtually any desired property can be
constructed from networks of simple regulatory elements. These properties, which include …