Lipoxygenases (LOXs) form a heterogeneous class of lipid peroxidizing enzymes, which
have been implicated not only in cell proliferation and differentiation but also in the …

Lipoxygenase (5-LOX) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid
mediators of inflammation derived from arachidonic acid. In this review we focus on 5-LOX …

Leukotrienes (LT) are lipid mediators of the inflammatory response that are linked to asthma
and atherosclerosis. LT biosynthesis is initiated by 5-lipoxygenase (5-LOX) with the …

Metabolism of arachidonic acid leads to several families of lipid mediators, including
prostaglandins, thromboxane, leukotrienes, and lipoxins, along two major metabolic …

There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …

▪ Abstract Lipid peroxidation is common to all biological systems, both appearing in
developmentally and environmentally regulated processes of plants. The hydroperoxy …

Crystallography supplies unparalleled detail on structural information critical for mechanistic
analyses; however, it is restricted to describing low energy conformations of …

In recent years, significant progress has been made in understanding the geometric and
electronic structures of the active sites of non-heme iron enzymes and the contributions of …

Lipoxygenase reactions may initiate the synthesis of a signaling molecule or be involved in
inducing structural or metabolic changes in the cell. For signaling, synthesis of a single fatty …

As succinctly summarized by Wolf, 1 lack of vitamin A (all-trans-retinol) was recognized by
ancient Egyptians as causing a visual deficiency involving the retina and cornea that could …