Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …

Cancer is one of the greatest challenges of the modern medicine. Although much effort has
been made in the development of novel cancer therapeutics, it still remains one of the most …

Microtubule plus-end tracking proteins (+ TIPs) control microtubule specialization and are as
such essential for cell division and morphogenesis. Here we investigated interactions and …

Microtubules are polarized intracellular polymers that play key roles in the cell, including in
transport, polarity, and cell division. Across eukaryotic cell types, microtubules adopt diverse …

Microtubule nucleation is mediated by γ-tubulin ring complexes (γ-TuRCs). In most
eukaryotes, a GCP4/5/4/6 “core” complex promotes γ-tubulin small complex (γ-TuSC) …

Kinesins are microtubule-dependent motor proteins, some of which moonlight as
microtubule polymerases, such as the yeast protein Kip2. Here, we show that the CLIP-170 …

To fulfill their actual cellular role, individual microtubules become functionally specialized
through a broad range of mechanisms. The 'search and capture'model posits that …

Microtubules are highly dynamic filaments with dramatic structural rearrangements and
length changes during the cell cycle. An accurate control of the microtubule length is …

Microtubules are ubiquitous cytoskeletal polymers with essential functions in chromosome
segregation, intracellular transport, and cellular morphogenesis. End-binding proteins (EBs) …

Faithful chromosome segregation requires the assembly of a bipolar spindle, consisting of
two antiparallel microtubule (MT) arrays having most of their minus ends focused at the …