Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

▪ Abstract We describe the formation, maturation, elimination, maintenance, and
regeneration of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses …

We generated transgenic mice in which red, green, yellow, or cyan fluorescent proteins
(together termed XFPs) were selectively expressed in neurons. All four XFPs labeled …

The brain is complex and dynamic. The spatial scales of interest to the neurobiologist range
from individual synapses (∼ 1 μm) to neural circuits (centimeters); the timescales range from …

The structural dynamics of synapses probably has a crucial role in the development and
plasticity of the nervous system. In the mammalian brain, the vast majority of excitatory axo …

Dendritic spines were imaged over days to months in the apical tufts of neocortical
pyramidal neurons (layers 5 and 2/3) in vivo. A fraction of thin spines appeared and …

The cellular basis of age-related behavioral decline remains obscure but alterations in
synapses are likely candidates. Accordingly, the beneficial effects on neural function of …

Synapse formation and elimination occur throughout life, but the magnitude of such changes
at distinct developmental stages remains unclear. Using transgenic mice overexpressing …

Effects of previous strength training can be long-lived, even after prolonged subsequent
inactivity, and retraining is facilitated by a previous training episode. Traditionally, such …

Blockade of acetylcholine release by botulinum neurotoxin type A at the neuromuscular
junction induces the formation of an extensive network of nerve-terminal sprouts. By …