Harnessing innate immune pathways for therapeutic advancement in cancer

A Hu, L Sun, H Lin, Y Liao, H Yang… - Signal Transduction and …, 2024 - nature.com
The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …

[HTML][HTML] Compartmentalization of the host microbiome: how tumor microbiota shapes checkpoint immunotherapy outcome and offers therapeutic prospects

M Boesch, L Horvath, F Baty, A Pircher… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
The host microbiome is polymorphic, compartmentalized, and composed of distinctive tissue
microbiomes. While research in the field of cancer immunotherapy has provided an …

The lung microbiome, peripheral gene expression, and recurrence-free survival after resection of stage II non-small cell lung cancer

BA Peters, HI Pass, RD Burk, X Xue, C Goparaju… - Genome medicine, 2022 - Springer
Background Cancer recurrence after tumor resection in early-stage non-small cell lung
cancer (NSCLC) is common, yet difficult to predict. The lung microbiota and systemic …

Alterations of lung microbiota in patients with non-small cell lung cancer

W Zeng, CZ Zhao, M Yu, H Chen, Y Pan, Y Wang… - …, 2022 - Taylor & Francis
The role of lung microbiota in non-small cell lung cancer remains unclear. We investigated
the characteristics and functional roles of lung microbiota in non-small cell lung cancer …

Neutrophil extracellular traps primed intercellular communication in cancer progression as a promising therapeutic target

B Shang, H Cui, R Xie, J Wu, H Shi, X Bi, L Feng… - Biomarker …, 2023 - Springer
In addition to the anti-infection response, neutrophils are linked to tumor progression
through the secretion of inflammation components and neutrophil extracellular traps (NETs) …

Correlation analysis of lung mucosa-colonizing bacteria with clinical features reveals metastasis-associated bacterial community structure in non-small cell lung …

W Wang, X Liang, H Kong, Y Yang, Y Xia, Q Wang… - Respiratory …, 2023 - Springer
Background Microbes colonizing lower airways can regulate the host immune profile and
consequently participate in lung disease. Increasing evidence indicate that individual …

CXCR1 correlates to poor outcomes of EGFR-TKI against advanced non-small cell lung cancer by activating chemokine and JAK/STAT pathway

F Yang, S Zhang, Q Meng, F Zhou, B Pan, F Liu… - Pulmonary …, 2021 - Elsevier
Objective CXCR1, a member of the seven-transmembrane chemokine receptor family,
promotes cell proliferation and metastasis in many tumors. The present study was …

The airway microbiota of non‐small cell lung cancer patients and its relationship to tumor stage and EGFR gene mutation

DH Huang, J He, XF Su, YN Wen, SJ Zhang… - Thoracic …, 2022 - Wiley Online Library
Background Accumulating studies have suggested the airway microbiota in lung cancer
patients is significantly different from that of healthy controls. However, little is known about …

Understanding the role of Toll-like receptors in lung cancer immunity and immunotherapy

B Hoden, D DeRubeis… - Frontiers in …, 2022 - frontiersin.org
Lung cancer is currently the leading cause of cancer-related deaths worldwide. Significant
improvements in lung cancer therapeutics have relied on a better understanding of lung …

Inhibition of LPS-mediated TLR4 activation abrogates gastric adenocarcinoma-associated peritoneal metastasis

V Sangwan, L Al-Marzouki, S Pal, V Stavrakos… - Clinical & Experimental …, 2022 - Springer
Surgical resection, the cornerstone of curative intent treatment for gastric adenocarcinoma,
is associated with a high rate of infection-related post-operative complications, leading to an …