Streptomyces: Still the Biggest Producer of New Natural Secondary Metabolites, a Current Perspective

L Donald, A Pipite, R Subramani, J Owen… - Microbiology …, 2022 - mdpi.com
There is a real consensus that new antibiotics are urgently needed and are the best chance
for combating antibiotic resistance. The phylum Actinobacteria is one of the main producers …

Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

[HTML][HTML] Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces

N Lee, S Hwang, J Kim, S Cho, B Palsson… - Computational and …, 2020 - Elsevier
Streptomyces are a large and valuable resource of bioactive and complex secondary
metabolites, many of which have important clinical applications. With the advances in high …

Structural diversity, biosynthesis, and biological functions of lipopeptides from Streptomyces

S Zhang, Y Chen, J Zhu, Q Lu, MJ Cryle… - Natural Product …, 2023 - pubs.rsc.org
Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

The extremophilic actinobacteria: from microbes to medicine

MLY Hui, LTH Tan, V Letchumanan, YW He, CM Fang… - Antibiotics, 2021 - mdpi.com
Actinobacteria constitute prolific sources of novel and vital bioactive metabolites for
pharmaceutical utilization. In recent years, research has focused on exploring actinobacteria …

Antimicrobial and antioxidant activities of Streptomyces species from soils of three different cold sites in the Fez-Meknes region Morocco

S Rammali, L Hilali, K Dari, B Bencharki, A Rahim… - Scientific reports, 2022 - nature.com
The increasing demand for new bioactive compounds to combat the evolution of multi-drug
resistance (MDR) requires research on microorganisms in different environments in order to …

Why do antibiotics exist?

F Spagnolo, M Trujillo, JJ Dennehy - MBio, 2021 - Am Soc Microbiol
In the struggle with antibiotic resistance, we are losing. There is now a serious threat of
moving into a postantibiotic world. High levels of resistance, in terms of both frequency and …

Recent advances in heterologous expression of natural product biosynthetic gene clusters in Streptomyces hosts

HS Kang, ES Kim - Current Opinion in Biotechnology, 2021 - Elsevier
The heterologous expression of natural product biosynthetic gene clusters (BGCs) has
traditionally been used as a genetic platform to link various natural product chemotypes to …

Pan-Genome of the Genus Streptomyces and Prioritization of Biosynthetic Gene Clusters With Potential to Produce Antibiotic Compounds

C Caicedo-Montoya, M Manzo-Ruiz… - Frontiers in …, 2021 - frontiersin.org
Species of the genus Streptomyces are known for their ability to produce multiple secondary
metabolites; their genomes have been extensively explored to discover new bioactive …

Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes

N Lee, S Hwang, W Kim, Y Lee, JH Kim, S Cho… - Natural Product …, 2021 - pubs.rsc.org
Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …