A key goal of cancer systems biology is to use big data to elucidate the molecular networks
by which cancer develops. However, to date there has been no systematic evaluation of how …

AXL is a receptor tyrosine kinase (RTK) that has been implicated in diverse tumor‐promoting
processes such as proliferation, migration, invasion, survival, and apoptosis. AXL therefore …

Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth
of tumors but often leads to the emergence of slowly dividing persister cells, which constitute …

Breast cancer was one of the first malignancies to benefit from targeted therapy, ie,
treatments directed against specific markers. Inhibitors against HER2 are a significant …

Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas
which lack effective drugs. Loss of the RAS GTPase-activating protein NF1 and subsequent …

A full understanding of cell signaling processes requires knowledge of protein structure–
function relationships, protein–protein interactions, and the abilities of pathways to control …

Resistance to targeted anti-cancer drugs is a complex phenomenon and a major challenge
in cancer treatment. It is becoming increasingly evident that a form of acquired drug …

The mitogen-activated protein kinase (MAPK) pathway is an important intracellular signaling
cascade that plays a key role in various cellular processes. Understanding the regulatory …

Anti-cancer drugs commonly target signal transduction proteins activated by mutation. In
patients with BRAFV600E melanoma, small molecule RAF and MEK kinase inhibitors cause …

The biophysical properties of ligand binding heavily influence the ability of receptors to
specify cell fates. Understanding the rules by which ligand binding kinetics impact cell …