Causal relationship between gastro-esophageal reflux disease and risk of lung cancer: insights from multivariable Mendelian randomization and mediation analysis

Y Liu, H Lai, R Zhang, L Xia, L Liu - International Journal of …, 2023 - academic.oup.com
Aim A recent study has reported that anti-reflux surgery reduced the risk of lung cancer.
However, the exact causal association between gastro-esophageal reflux disease (GORD) …

Causal associations between gastroesophageal reflux disease and lung cancer risk: A Mendelian randomization study

L Li, Q Ren, Q Zheng, Y Bai, S He, Y Zhang… - Cancer …, 2023 - Wiley Online Library
Background Observational epidemiological studies suggest that lung cancer risk may be
raised by gastroesophageal reflux disease (GERD); however, the causal relationship …

[HTML][HTML] Chronic obstructive pulmonary disease and risk of lung cancer: a meta-analysis of prospective cohort studies

X Zhang, N Jiang, L Wang, H Liu, R He - Oncotarget, 2017 - ncbi.nlm.nih.gov
Background Studies exploring the association between chronic obstructive pulmonary
disease (COPD) and lung cancer have yielded mixed results. We conducted a meta …

[HTML][HTML] The role of smoking and alcohol in mediating the effect of gastroesophageal reflux disease on lung cancer: A Mendelian randomization study

J Yang, D Nie, Y Chen, Z Liu, M Li, C Gong… - Frontiers in …, 2023 - frontiersin.org
Observational studies have suggested a positive association between gastroesophageal
reflux disease and lung cancer, but due to the existence of confounders, it remains …

[HTML][HTML] Association between EGFR mutation and ageing, history of pneumonia and gastroesophageal reflux disease among patients with advanced lung cancer

WI Choi, J Jeong, CW Lee - European Journal of Cancer, 2019 - Elsevier
Background Epidermal growth factor receptor (EGFR) mutation is the most frequently
encountered oncogenic driver in lung cancer. Risk factors for EGFR mutation may help …

Gastroesophageal reflux disease increases the risk of essential hypertension: results from the Nationwide Readmission Database and Mendelian randomization …

Z Yao, C Zhao, Y Zhang, X Fan… - Postgraduate Medical …, 2024 - academic.oup.com
Background The link between gastroesophageal reflux disease (GERD) and essential
hypertension (EH) and its causal nature remains controversial. Our study examined the …

[HTML][HTML] Gastroesophageal reflux disease and the risk of respiratory diseases: a Mendelian randomization study

R Dong, Q Zhang, H Peng - Journal of Translational Medicine, 2024 - Springer
Background Observational studies have suggested a suspected association between
gastroesophageal reflux disease (GERD) and respiratory diseases, but the causality …

Survival after antireflux surgery versus medication in patients with reflux oesophagitis or Barrett's oesophagus: multinational cohort study

M Yanes, G Santoni, J Maret-Ouda… - British Journal of …, 2021 - academic.oup.com
Background The aim was to examine the hypothesis that antireflux surgery with
fundoplication improves long-term survival compared with antireflux medication in patients …

Gastroesophageal reflux disease and risk of cancer: Findings from the Korean National Health Screening Cohort

CL Tran, M Han, B Kim, EY Park, YI Kim… - Cancer …, 2023 - Wiley Online Library
Aim Little is known about the association of cancers other than esophageal adenocarcinoma
with gastroesophageal reflux disease (GERD). This study aimed to examine the association …

[HTML][HTML] Antireflux surgery and risk of lung cancer by histological type in a multinational cohort study

M Yanes, G Santoni, J Maret-Ouda… - European Journal of …, 2020 - Elsevier
Introduction Airway micro-aspiration might contribute to the proposed associations between
gastroesophageal reflux disease (GERD) and some lung diseases, including lung cancer …