[HTML][HTML] A high-throughput, bead-based, antigen-specific assay to assess the ability of antibodies to induce complement activation
S Fischinger, JK Fallon, AR Michell, T Broge… - Journal of …, 2019 - Elsevier
The complement system plays a critical role in innate immune defense against pathogens,
both via non-specific direct pathogen recognition and killing or via antigen-specific indirect …
both via non-specific direct pathogen recognition and killing or via antigen-specific indirect …
Interaction between the complement system and infectious agents–a potential mechanistic link to neurodegeneration and dementia
As part of the innate immune system, complement plays a critical role in the elimination of
pathogens and mobilization of cellular immune responses. In the central nervous system …
pathogens and mobilization of cellular immune responses. In the central nervous system …
Enhanced complement activation and MAC formation accelerates severe COVID-19
CR Ellsworth, Z Chen, MT Xiao, C Qian… - Cellular and Molecular …, 2024 - Springer
Emerging evidence indicates that activation of complement system leading to the formation
of the membrane attack complex (MAC) plays a detrimental role in COVID-19. However …
of the membrane attack complex (MAC) plays a detrimental role in COVID-19. However …
Emerging role of complement in COVID-19 and other respiratory virus diseases
The complement system, a key component of innate immunity, provides the first line of
defense against bacterial infection; however, the COVID-19 pandemic has revealed that it …
defense against bacterial infection; however, the COVID-19 pandemic has revealed that it …
HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis
J Nitkiewicz, A Borjabad, S Morgello, J Murray… - Journal of …, 2017 - Springer
Background Abnormal activation of the complement system contributes to some central
nervous system diseases but the role of complement in HIV-associated neurocognitive …
nervous system diseases but the role of complement in HIV-associated neurocognitive …
[HTML][HTML] The Association between IL-1β and IL-18 Levels, Gut Barrier Disruption, and Monocyte Activation during Chronic Simian Immunodeficiency Virus Infection …
S Thirugnanam, C Wang, C Zheng… - International Journal of …, 2024 - mdpi.com
HIV-induced persistent immune activation is a key mediator of inflammatory comorbidities
such as cardiovascular disease (CVD) and neurocognitive disorders. While a …
such as cardiovascular disease (CVD) and neurocognitive disorders. While a …
[HTML][HTML] IgG3 collaborates with IgG1 and IgA to recruit effector function in RV144 vaccinees
S Fischinger, S Dolatshahi, MF Jennewein… - JCI insight, 2020 - ncbi.nlm.nih.gov
While the RV144 HIV vaccine trial led to moderately reduced risk of HIV acquisition,
emerging data from the HVTN702 trial point to the critical need to reexamine RV144-based …
emerging data from the HVTN702 trial point to the critical need to reexamine RV144-based …
[HTML][HTML] Coupling of Alzheimer's Disease Genetic Risk Factors with Viral Susceptibility and Inflammation
C Cao, G Fu, R Xu, N Li - Aging and Disease, 2024 - pmc.ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a neurodegenerative disease characterized by persistent
cognitive decline. Amyloid plaque deposition and neurofibrillary tangles are the main …
cognitive decline. Amyloid plaque deposition and neurofibrillary tangles are the main …
HIV-Tat regulates macrophage gene expression in the context of neuroAIDS
L Carvallo, L Lopez, JE Fajardo… - PloS one, 2017 - journals.plos.org
Despite the success of cART, greater than 50% of HIV infected people develop cognitive
and motor deficits termed HIV-associated neurocognitive disorders (HAND). Macrophages …
and motor deficits termed HIV-associated neurocognitive disorders (HAND). Macrophages …