Antiviral effect of phytochemicals from medicinal plants: Applications and drug delivery strategies

S Ben-Shabat, L Yarmolinsky, D Porat… - Drug delivery and …, 2020 - Springer
Viral infections affect three to five million patients annually. While commonly used antivirals
often show limited efficacy and serious adverse effects, herbal extracts have been in use for …

Improvement strategies for the oral bioavailability of poorly water-soluble flavonoids: An overview

J Zhao, J Yang, Y Xie - International journal of pharmaceutics, 2019 - Elsevier
Although flavonoid compounds have various pharmacological applications, they generally
exhibit low oral bioavailability due to their poor aqueous solubility. To address this problem …

Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development

CR Ferraz, TT Carvalho, MF Manchope, NA Artero… - Molecules, 2020 - mdpi.com
Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a
consequence of the pathological functioning of the nervous system rather than only a …

Novel Carboxymethyl Cellulose-Based Hydrogel with Core–Shell Fe3O4@SiO2 Nanoparticles for Quercetin Delivery

M Mahdi Eshaghi, M Pourmadadi, A Rahdar… - Materials, 2022 - mdpi.com
A nanocomposite composed of carboxymethyl cellulose (CMC) and core–shell
nanoparticles of Fe3O4@ SiO2 was prepared as a pH-responsive nanocarrier for quercetin …

Natural product-based nanomedicine: recent advances and issues

R Watkins, L Wu, C Zhang, RM Davis… - International journal of …, 2015 - Taylor & Francis
Natural products have been used in medicine for many years. Many top-selling
pharmaceuticals are natural compounds or their derivatives. These plant-or microorganism …

Novel drug delivery systems for loading of natural plant extracts and their biomedical applications

HS Rahman, HH Othman, NI Hammadi… - International journal …, 2020 - Taylor & Francis
Many types of research have distinctly addressed the efficacy of natural plant metabolites
used for human consumption both in cell culture and preclinical animal model systems …

Improved oral absorption of quercetin from quercetin phytosome®, a new delivery system based on food grade lecithin

A Riva, M Ronchi, G Petrangolini, S Bosisio… - European journal of …, 2019 - Springer
Abstract Background and Objectives The importance of quercetin and flavonoids in the diet
and as food supplements is well known, and literature studies support their potential use to …

Nanoemulsion: Promising nanocarrier system for delivery of herbal bioactives

RK Harwansh, R Deshmukh, MA Rahman - Journal of Drug Delivery …, 2019 - Elsevier
The herbal medicines have been popularized throughout the globe since time immemorial.
Several plant based therapeutic leads have been produced through integrated approaches …

Technological and biotechnological processes to enhance the bioavailability of dietary (poly) phenols in humans

F Polia, M Pastor-Belda… - Journal of agricultural …, 2022 - ACS Publications
The health effects of (poly) phenols (PPs) depend upon their bioavailability that, in general,
is very low and shows a high interindividual variability. The low bioavailability of PPs is …

Endogenous and exogenous mediators of quercetin bioavailability

Y Guo, RS Bruno - The Journal of nutritional biochemistry, 2015 - Elsevier
Quercetin is a dietary flavonol that has poor and highly variable bioavailability.
Epidemiological studies suggest that higher dietary intakes of quercetin decease …