Mitochondrial impairment: A common motif in neuropsychiatric presentation? The link to the tryptophan–kynurenine metabolic system

M Tanaka, Á Szabó, E Spekker, H Polyák, F Tóth… - Cells, 2022 - mdpi.com
Nearly half a century has passed since the discovery of cytoplasmic inheritance of human
chloramphenicol resistance. The inheritance was then revealed to take place maternally by …

From CGRP to PACAP, VIP, and beyond: unraveling the next chapters in migraine treatment

M Tanaka, Á Szabó, T Körtési, D Szok, J Tajti, L Vécsei - Cells, 2023 - mdpi.com
Migraine is a neurovascular disorder that can be debilitating for individuals and society.
Current research focuses on finding effective analgesics and management strategies for …

Editorial of special issue 'dissecting neurological and neuropsychiatric diseases: Neurodegeneration and neuroprotection'

M Tanaka, L Vécsei - International journal of molecular sciences, 2022 - mdpi.com
This Special Issue has focused on dissecting the neuroprotective and neurodegenerative
components of neurological and neuropsychiatric diseases, highlighting the latest advance …

The tryptophan-kynurenine metabolic system is suppressed in cuprizone-induced model of demyelination simulating progressive multiple sclerosis

H Polyák, Z Galla, N Nánási, EK Cseh, C Rajda… - Biomedicines, 2023 - mdpi.com
Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is
histologically classified into the subpial type 3 lesions in the autopsy. The lesion is also …

[PDF][PDF] The tryptophan-kynurenine metabolic system is suppressed in cuprizone-induced model of demyelination simulating progressive multiple sclerosis., 2023, 11 …

H Polyák, Z Galla, N Nánási, EK Cseh… - DOI: https://doi. org …, 2023 - researchgate.net
Progressive multiple sclerosis (MS) is a chronic disease with a unique pattern, which is
histologically classified into the subpial type 3 lesions in the autopsy. The lesion is also …

[HTML][HTML] Kisspeptin-10 Mitigates α-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner

C Simon, T Soga, I Parhar - International Journal of Molecular Sciences, 2023 - mdpi.com
The hypothalamic neurohormone kisspeptin-10 (KP-10) was inherently implicated in
cholinergic pathologies when aberrant fluctuations of expression patterns and receptor …

Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP

J Oláh, V Norris, A Lehotzky, J Ovádi - Cells, 2024 - mdpi.com
Neurological disorders such as Parkinsonism cause serious socio-economic problems as
there are, at present, only therapies that treat their symptoms. The well-established hallmark …

Nasal application of kisspeptin-54 mitigates motor deficits by reducing nigrostriatal dopamine loss in hemiparkinsonian rats

O Sinen, AG Sinen, N Derin, MA Aslan - Behavioural Brain Research, 2024 - Elsevier
Parkinson's Disease is a progressive neurodegenerative disorder characterized by motor
symptoms resulting from the loss of nigrostriatal dopaminergic neurons. Kisspeptins (KPs) …

[PDF][PDF] Unraveling the Neurobiological Roots of Despair: Insights from Novel Kynurenine Aminotransferase II Knockout Mice

Á Szabó, E Spekker, M Szűcs, K Takeda, K Ozaki… - 2023 - researchgate.net
Memory and emotion, fundamental components of our mental existence, are highly
vulnerable to psychiatric disorders like post-traumatic stress disorder (PTSD). This condition …

Exploring the Neurobiological Roots of Emotional Behavior in Tryptophan Metabolism: Insights from Novel Kynurenine Aminotransferase Knockout Mice

Á Szabó, E Spekker, M Szűcs, K Takeda, K Ozaki… - 2023 - preprints.org
Memory and emotion, fundamental components of our mental existence, are highly
vulnerable to psychiatric disorders like post-traumatic stress disorder (PTSD). This condition …