Origins of DNA replication in eukaryotes
Y Hu, B Stillman - Molecular Cell, 2023 - cell.com
Errors occurring during DNA replication can result in inaccurate replication, incomplete
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
replication, or re-replication, resulting in genome instability that can lead to diseases such as …
[HTML][HTML] DNA replication and replication stress response in the context of nuclear architecture
D González-Acosta, M Lopes - Chromosoma, 2024 - Springer
The DNA replication process needs to be coordinated with other DNA metabolism
transactions and must eventually extend to the full genome, regardless of chromatin status …
transactions and must eventually extend to the full genome, regardless of chromatin status …
[HTML][HTML] High-resolution Repli-Seq defines the temporal choreography of initiation, elongation and termination of replication in mammalian cells
PA Zhao, T Sasaki, DM Gilbert - Genome biology, 2020 - Springer
Background DNA replication in mammalian cells occurs in a defined temporal order during
S phase, known as the replication timing (RT) programme. Replication timing is …
S phase, known as the replication timing (RT) programme. Replication timing is …
[HTML][HTML] Involvement of G-quadruplex regions in mammalian replication origin activity
P Prorok, M Artufel, A Aze, P Coulombe, I Peiffer… - Nature …, 2019 - nature.com
Genome-wide studies of DNA replication origins revealed that origins preferentially
associate with an Origin G-rich Repeated Element (OGRE), potentially forming G …
associate with an Origin G-rich Repeated Element (OGRE), potentially forming G …
[PDF][PDF] Meiotic recombination mirrors patterns of germline replication in mice and humans
Genetic recombination generates novel trait combinations, and understanding how
recombination is distributed across the genome is key to modern genetics. The PRDM9 …
recombination is distributed across the genome is key to modern genetics. The PRDM9 …
Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy
During routine genome duplication, many potential replication origins remain inactive or
'dormant'. Such origin dormancy is achieved, in part, by an interaction with the metabolic …
'dormant'. Such origin dormancy is achieved, in part, by an interaction with the metabolic …
[HTML][HTML] A predictable conserved DNA base composition signature defines human core DNA replication origins
DNA replication initiates from multiple genomic locations called replication origins. In
metazoa, DNA sequence elements involved in origin specification remain elusive. Here, we …
metazoa, DNA sequence elements involved in origin specification remain elusive. Here, we …
[PDF][PDF] Loss of Ezh2 function remodels the DNA replication initiation landscape
In metazoan cells, DNA replication initiates from thousands of genomic loci scattered
throughout the genome called DNA replication origins. Origins are strongly associated with …
throughout the genome called DNA replication origins. Origins are strongly associated with …
[PDF][PDF] Replication stress shapes a protective chromatin environment across fragile genomic regions
Recent integrative epigenome analyses highlight the importance of functionally distinct
chromatin states for accurate cell function. How these states are established and maintained …
chromatin states for accurate cell function. How these states are established and maintained …
BEND3 safeguards pluripotency by repressing differentiation-associated genes
F Kurniawan, N Chetlangia… - Proceedings of the …, 2022 - National Acad Sciences
BEN domain–containing proteins are emerging rapidly as an important class of factors
involved in modulating gene expression, yet the molecular basis of how they regulate …
involved in modulating gene expression, yet the molecular basis of how they regulate …