Cyclophilins, enzymes with peptidyl‐prolyl cis/trans isomerase activity, are relevant to a
large variety of biological processes. The most abundant member of this enzyme family …

Cyclophilin A (CypA), a key member of the immunophilin family, is the most abundantly
expressed isozyme of the 18 known human cyclophilins. Besides acting as an intracellular …

Background & Aims Hepatic ischemia/reperfusion injury is a complication of liver surgery
that involves mitochondrial dysfunction resulting from mitochondrial permeability transition …

Cyclophilins (Cyps) are a subgroup of peptidyl-prolyl cis-trans isomerases (PPIases) that
contain a highly conserved domain of PPIases. Sixteen Cyps have been identified in …

Introduction: Cyclophilins are a family of diverse regulatory enzymes that have been studied
for over 30 years; they participate in many pathophysiological processes. Genetic deletion or …

Cyclophilin (Cyp) inhibitors are of clinical interest in respect to their antiviral activities in the
context of many viral infections including chronic hepatitis B and C. Cyps are a group of …

Implicated in numerous human diseases, intrinsically disordered proteins (IDPs) are
dynamic ensembles of interconverting conformers that often contain many proline residues …

Cyclophilin A, a widely prevalent cellular protein, exhibits peptidyl-prolyl cis-trans isomerase
activity. This protein is predominantly located in the cytosol; additionally, it can be secreted …

Background In hepatitis C virus (HCV) infection, treatment failure is generally associated
with the selection of resistance‐associated substitutions (RAS) conferring reduced …

Cyclophilins are cellular peptidyl-prolyl isomerases that play an important role in viral
infections, with demonstrated roles in the replication of hepatitis C virus (HCV) and other …