The transforming growth factor-beta (TGF-β) signaling pathway is a vital regulator of cell
proliferation, differentiation, apoptosis, and extracellular matrix production. It functions …

Lung cancer is the leading cause of cancer death in the US with survival restricted to a
subset of those patients able to undergo surgical resection. However, even with surgery …

BACKGROUND Transforming growth factor‐β1 (TGF‐β1) is a multifunctional factor and is
known to affect tumor growth in malignant tumors. The effects of TGF‐β1 on angiogenesis …

Transforming growth factor-β (TGF-β) is a multifunctional cytokine, with important roles in
maintaining tissue homeostasis. TGF-β signals via transmembrane serine/threonine kinase …

Lung cancer is the largest cancer killer of men and women in the united states. In addition to
the progress made from antismoking primary prevention measures, new tools to help treat …

Characteristics of the tumour that affect and predict the survival outcome of patients with
cancer are prognostic markers for cancer. In non-small cell lung carcinoma (NSCLC), stage …

Paradoxically, during early tumor development in many cancer types, TGF-β acts as a tumor
suppressor, whereas in the advanced stages of these cancers, increased TGF-β expression …

Lung cancer is a leading cause of cancer deaths. As a solid tumor with low antigenicity and
heterogenic phenotype lung cancer evades host immune defense. The cytotoxic anticancer …

Transforming growth factor (TGF)-β1 is associated with tumor progression and resistance to
chemotherapy in established cancers, as well as host immune suppression. Here, we show …

TIF1γ is a novel regulator of transforming growth factor (TGF)-β/Smad signaling. Our
previous studies show that dysregulated expression of transcriptional intermediary factor 1 γ …