Why Plasmodium vivax and Plasmodium falciparum are so different? A tale of two clades and their species diversities

AA Escalante, AS Cepeda, MA Pacheco - Malaria Journal, 2022 - Springer
The global malaria burden sometimes obscures that the genus Plasmodium comprises
diverse clades with lineages that independently gave origin to the extant human parasites …

Repetitive sequences in malaria parasite proteins

HM Davies, SD Nofal, EJ McLaughlin… - FEMS microbiology …, 2017 - academic.oup.com
Five species of parasite cause malaria in humans with the most severe disease caused by
Plasmodium falciparum. Many of the proteins encoded in the P. falciparum genome are …

Effect of the aggregated protein dye YAT2150 on Leishmania parasite viability

L Román-Álamo, Y Avalos-Padilla… - Antimicrobial Agents …, 2024 - Am Soc Microbiol
The problems associated with the drugs currently used to treat leishmaniasis, including
resistance, toxicity, and the high cost of some formulations, call for the urgent identification of …

[PDF][PDF] Low complexity regions in proteins and DNA are poorly correlated

JM Enright, ZW Dickson… - Molecular Biology and …, 2023 - academic.oup.com
Low complexity sequences (LCRs) are well known within coding as well as non-coding
sequences. A low complexity region within a protein must be encoded by the underlying …

Population-level genome-wide STR discovery and validation for population structure and genetic diversity assessment of Plasmodium species

J Han, JE Munro, A Kocoski, AE Barry, M Bahlo - PLoS Genetics, 2022 - journals.plos.org
Short tandem repeats (STRs) are highly informative genetic markers that have been used
extensively in population genetics analysis. They are an important source of genetic …

Genomics of apicomplexan parasites

LS Swapna, J Parkinson - Critical Reviews in Biochemistry and …, 2017 - Taylor & Francis
The increasing prevalence of infections involving intracellular apicomplexan parasites such
as Plasmodium, Toxoplasma, and Cryptosporidium (the causative agents of malaria …

Genome evolution in intracellular parasites: Microsporidia and Apicomplexa

A Khalaf, O Francis, ML Blaxter - Journal of Eukaryotic …, 2024 - Wiley Online Library
Microsporidia and Apicomplexa are eukaryotic, single‐celled, intracellular parasites with
huge public health and economic importance. Typically, these parasites are studied …

Comparative analysis of low complexity regions in Plasmodia

SR Chaudhry, N Lwin, D Phelan, AA Escalante… - Scientific reports, 2018 - nature.com
Low complexity regions (LCRs) are a common feature shared by many genomes, but their
evolutionary and functional significance remains mostly unknown. At the core of the …

[HTML][HTML] Protein quality control machinery in intracellular protozoan parasites: hopes and challenges for therapeutic targeting

M Anas, V Kumari, N Gupta, A Dube… - Cell Stress and …, 2019 - Elsevier
Intracellular protozoan parasites have evolved an efficient protein quality control (PQC)
network comprising protein folding and degradation machineries that protect the parasite's …

Comparative proteomics uncovers low asparagine content in Plasmodium tRip‐KO proteins

M Pitolli, M Cela, D Kapps, J Chicher, L Despons… - IUBMB …, 2024 - Wiley Online Library
Abstract tRNAs are not only essential for decoding the genetic code, but their abundance
also has a strong impact on the rate of protein production, folding, and on the stability of the …