Blood vessel endothelial cells (ECs) have long been known to modulate inflammation by
regulating immune cell trafficking, activation status and function. However, whether the …

Microglia are emerging as critical regulators of neuronal function and behavior in nearly
every area of neuroscience. Initial reports focused on classical immune functions of …

The incidence of depression and anxiety is amplified by obesity. Mounting evidence reveals
that the psychiatric consequences of obesity stem from poor diet, inactivity, and visceral …

Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

Psychiatric disorders are highly prevalent, often devastating diseases that negatively impact
the lives of millions of people worldwide. Although their etiological and diagnostic …

The blood–brain barrier (BBB) is an important physiological barrier that separates the
central nervous system (CNS) from the peripheral circulation, which contains inflammatory …

Some recent clinical and preclinical evidence suggests that neuroinflammation is a key
factor that interacts with the three neurobiological correlates of major depressive disorder …

Stress is an inevitable part of life. Chronic stress on account of reasons like adversity,
depression, anxiety, or loneliness/social isolation can endanger human health. Recent …

Background: Frailty is a multidimensional condition often diagnosed in older adults with
hypertension and diabetes, and both these conditions are associated with endothelial …

Over the last 50 years, the concept of stress has evolved significantly, and our
understanding of the underlying neurobiology has expanded dramatically. Rather than …