Plasmodium falciparum resistance to chloroquine and sulphadoxine–pyrimethamine has led
to the recent adoption of artemisinin-based combination therapies (ACTs) as the first line of …

Blocking malaria transmission is critical to malaria control programs but remains a major
challenge especially in endemic regions with high levels of asymptomatic infections. New …

Background Artemisinin combination therapies (ACT), which are increasingly being
introduced for treatment of Plasmodium falciparum malaria, are more effective against …

Conversion from asexual proliferation to sexual differentiation initiates the production of the
gametocyte, which is the malaria parasite stage required for human-to-mosquito …

A major determinant of the rate at which drug-resistant malaria parasites spread through a
population is the ecology of resistant and sensitive parasites sharing the same host. Drug …

The scientific community worldwide has realized that malaria elimination will not be possible
without development of safe and effective transmission-blocking interventions. Primaquine …

Only chlorpheniramine has so far shown some clinical utility as a chloroquine resistance
reverser. Recent observations, however, that both primaquine and HIV protease inhibitors …

Although the illness malaria is caused by the asexual blood stages, the presence of
gametocytes is directly responsible for the infection of the vector Anopheles, thus …

The treatment efficacy and effects of artemether-lumefantrine (AL) and amodiaquine-
sulfalenepyrimethamine (ASP) on gametocyte carriage were evaluated in 181 children 10 …

Plasmodium falciparum with reduced sensitivity to artemisinin derivatives has been
observed in endemic areas, but the molecular mechanisms for this reduced sensitivity …