Epidermal growth factor receptor cell proliferation signaling pathways
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer …
The interdependent activation of Son-of-Sevenless and Ras
The guanine-nucleotide exchange factor (GEF) Son-of-Sevenless (SOS) plays a critical role
in metazoan signaling by converting Ras• GDP (guanosine diphosphate) to Ras• GTP …
in metazoan signaling by converting Ras• GDP (guanosine diphosphate) to Ras• GTP …
Mechanism of SOS PR-domain autoinhibition revealed by single-molecule assays on native protein from lysate
The guanine nucleotide exchange factor (GEF) Son of Sevenless (SOS) plays a critical role
in signal transduction by activating Ras. Here we introduce a single-molecule assay in …
in signal transduction by activating Ras. Here we introduce a single-molecule assay in …
Novel regulation of Ras proteins by direct tyrosine phosphorylation and dephosphorylation
Somatic mutations in the RAS genes are frequent in human tumors, especially in pancreatic,
colorectal, and non-small-cell lung cancers. Such mutations generally decrease the ability of …
colorectal, and non-small-cell lung cancers. Such mutations generally decrease the ability of …
RAS signaling in carcinogenesis, cancer therapy and resistance mechanisms
X Yang, H Wu - Journal of Hematology & Oncology, 2024 - Springer
Variants in the RAS family (HRAS, NRAS and KRAS) are among the most common
mutations found in cancer. About 19% patients with cancer harbor RAS mutations, which are …
mutations found in cancer. About 19% patients with cancer harbor RAS mutations, which are …
One-way membrane trafficking of SOS in receptor-triggered Ras activation
SM Christensen, HL Tu, JE Jun, S Alvarez… - Nature structural & …, 2016 - nature.com
SOS is a key activator of the small GTPase Ras. In cells, SOS-Ras signaling is thought to be
initiated predominantly by membrane recruitment of SOS via the adaptor Grb2 and balanced …
initiated predominantly by membrane recruitment of SOS via the adaptor Grb2 and balanced …
[HTML][HTML] Interaction domains of Sos1/Grb2 are finely tuned for cooperative control of embryonic stem cell fate
Metazoan evolution involves increasing protein domain complexity, but how this relates to
control of biological decisions remains uncertain. The Ras guanine nucleotide exchange …
control of biological decisions remains uncertain. The Ras guanine nucleotide exchange …
Small molecule–mediated activation of RAS elicits biphasic modulation of Phospho-ERK levels that are regulated through negative feedback on SOS1
JE Howes, DT Akan, MC Burns, OW Rossanese… - Molecular Cancer …, 2018 - AACR
Oncogenic mutation of RAS results in aberrant cellular signaling and is responsible for more
than 30% of all human tumors. Therefore, pharmacologic modulation of RAS has attracted …
than 30% of all human tumors. Therefore, pharmacologic modulation of RAS has attracted …
Expressions and clinical significances of c-MET, p-MET and E2f-1 in human gastric carcinoma
J Wu, J Yu, H Wu, L Zheng, X Ni, X Li, G Du, B Jiang - BMC research notes, 2014 - Springer
Background To investigate on the expressions and the clinical significances of hepatocyte
growth factor receptor (c-MET), phosphorylated c-MET (p-MET) and e2f-1 transcription factor …
growth factor receptor (c-MET), phosphorylated c-MET (p-MET) and e2f-1 transcription factor …
Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation
S Pierre, AS Bats, A Chevallier, LC Bui… - Biochemical …, 2011 - Elsevier
TCDD (2, 3, 7, 8-tetrachlorodibenzodioxin), a highly persistent environmental pollutant and a
human carcinogen, is the ligand with the highest affinity for the Aryl Hydrocarbon Receptor …
human carcinogen, is the ligand with the highest affinity for the Aryl Hydrocarbon Receptor …