Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that
affects synovial joints, both small and large joints, in a symmetric pattern. This disorder …

Pathologic T cell–B cell interactions underlie many autoimmune diseases. The T cells that
help B cells in autoimmune diseases vary in phenotype and include T cells that lack typical …

Much remains unknown about the roles of CD4+ T helper cells in shaping localized memory
B cell and CD8+ T cell immunity in the mucosal tissues. Here, we report that lung T helper …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by pathologic
T cell–B cell interactions and autoantibody production. Defining the T cell populations that …

Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple
immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated …

Synovial tissue is a membranous non-immune organ lining joint cavities where it supports
local immune responses, and functions directly and indirectly in joint destruction due to …

Rheumatoid arthritis (RA) is one of the most common autoimmune diseases affecting
primarily the joints. Despite successful therapies including antibodies against tumor necrosis …

Background A major current challenge is to exploit tertiary lymphoid structures (TLSs) to
promote the lymphocyte infiltration, activation and differentiation by tumor antigens to …

Background CA125 is the best available yet insufficiently sensitive biomarker for early
detection of ovarian cancer. There is a need to identify novel biomarkers, which individually …

Introduction Tumour-reactive T cells producing the B-cell attractant chemokine CXCL13, in
solid tumours, promote development of tertiary lymphoid structures (TLS) and are associated …