The development of responsive biomaterials capable of demonstrating modulated function
in response to dynamic physiological and mechanical changes in vivo remains an important …

Growth factors play a crucial role in tissue engineering by directing the fate of cells and
allowing the formation of tissues. Understanding the key requirements for growth factor …

Facial deformities require precise reconstruction of the appearance and function of the
original tissue. The current standard of care—the use of bone harvested from another region …

Effective regeneration of bone defects often presents significant challenges, particularly in
patients with decreased tissue regeneration capacity due to extensive trauma, disease …

Congenital defects, trauma, and disease can compromise the integrity and functionality of
the skeletal system to the extent requiring implantation of bone grafts. Engineering of viable …

Bone graft material is often required for the treatment of osseous defects. However, due to
limitations and risks associated with autologous as well as allogenic bone grafting …

In recent years, our scientific interest in spaceflight has grown exponentially and resulted in
a thriving area of research, with hundreds of astronauts spending months of their time in …

Large bone defects are a major global health concern. Bone tissue engineering (BTE) is the
most promising alternative to avoid the drawbacks of autograft and allograft bone …

Tissue engineering has emerged as a possible alternative to current treatments for bone
injuries and defects. However, the common tissue engineering approach presents some …

In extensive bone defects, tissue damage and hypoxia lead to cell death, resulting in slow
and incomplete healing. Human embryonic stem cells (hESC) can give rise to all specialized …