Poor water-solubility remains a typical property of drug candidates in pharmaceutical
development pipelines today. Various processes have been developed to increase the …

Amorphous solid dispersions are an increasingly important formulation approach to improve
the dissolution rate and apparent solubility of poorly water soluble compounds. Due to their …

The aim of this study was to probe the dissolution mechanisms of amorphous solid
dispersions (ASDs) of a poorly water-soluble drug formulated with a hydrophilic polymer …

New chemical entities are required to possess physicochemical characteristics that result in
acceptable oral absorption. However, many promising candidates need physicochemical …

Melt extrusion (ME) over recent years has found widespread application as a viable drug
delivery option in the drug development process. ME applications include taste masking …

The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Electrospinning (ES) and extrusion of a poorly water-soluble active pharmaceutical
ingredient were used to improve its dissolution, which is a major challenge in the field of …

The objective of this study was to investigate the phase behavior of amorphous solid
dispersions composed of a hydrophobic drug and a hydrophilic polymer following exposure …

The in vitro dissolution mechanism of an amorphous solid dispersion (ASD) remains elusive
and highly individualized, yet rational design of ASDs with optimal performance and …

Introduction: Amorphous solid dispersions are considered as one of the most powerful
strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical …