Requirement of the N-terminal region of nonstructural protein 1 in cis for SARS-CoV-2 defective RNA replication

K Terasaki, S Makino - Journal of virology, 2024 - journals.asm.org
ABSTRACT SARS-CoV-2 belongs to the family Coronaviridae and carries a single-stranded
positive-sense RNA genome. During coronavirus (CoV) replication, defective or defective …

Exploring the treatment of SARS-CoV-2 with modified vesicular stomatitis virus

N Polavarapu, M Doty, HM Dobrovolny - Journal of Theoretical Biology, 2024 - Elsevier
SARS-CoV-2 caused a global pandemic and is now an endemic virus that will require
continued antiviral and vaccine development. A possible new treatment modality was …

Exploring the therapeutic potential of defective interfering particles in reducing the replication of SARS-CoV-2

M Locke, D Grebennikov, I Sazonov, M López-García… - Mathematics, 2024 - mdpi.com
SARS-CoV-2 still presents a global threat to human health due to the continued emergence
of new strains and waning immunity among vaccinated populations. Therefore, it is still …

The EXPLORATION OF THE THERAPEUTIC AND BIOTECHNOLOGICAL APPLICATIONS OF DEFECTIVE INTERFERING VIRUSES AND PARTICLES (DIVSDIPS) IN …

AB Hejran, S Sediqi, A Sarwari… - Вестник КазНУ …, 2024 - bulletin-ecology.kaznu.kz
Defective interfering viruses and particles (DIVs/DIPs) are viral mutants that arise during viral
replication, exerting significant effects on viral pathogenesis and host immune responses …

Understanding viral infections using mathematical models and statistical analysis

MW Locke - 2023 - etheses.whiterose.ac.uk
There are a range of viruses that exist, that not only infect humans, but also a wide range of
other species. These viruses not only present a threat to human health but also to …